Determinants of Severity and Outcome Among Young Adults with COVID 19

ABSTRACT

Background:Accumulating studies have suggested that all ages people are susceptible to SARS-CoV-2 infection, which can result in severe and even fatal respiratory diseases. The present study is to evaluate the determinants of disease severity and death among young adults affected with COVID-19. Materials and Methods: This prospective study includes a cohort of 100 adult patients who presented to Victoria Hospital and Bowring and Lady Curzon Hospital attached to BMCRI, Bangalore and were diagnosed with Covid-19 between May 2021 to August 2021. Patients were diagnosed with Covid-19 when symptomatic for Covid-like symptoms and had a positive SARS-CoV-2 nasopharyngeal PCR. Results: There was no significant association between sex and outcome. Proportions of comorbidities was higher among the non-survivors, however no significant association. This study showed that significantly higher pulse rate (95±16 vs 115±19), respiratory rate (22±4vs26±3), TC (11699.1±4624.2vs15053.5±7988.6), Urea (38.6±35.4vs63.2±75.7) and HRCT thorax (12±6vs18±5) was found among the non survivors, compared to survivors, p<0.05. Conclusion: Comparing with studies of all-age patients, a lot of clinical factors such as sex, comorbidities and some clinical symptoms, showed no significant difference between non-survivors and survivors in severely young adults, indicating that characters of young adults were far more different from older patients in severe COVID-19. We hence propose that vitals, Total counts, RFT values especially in CKD patients and HRCT thorax severity score should be assessed upon admission for patients, despite not previously documented among young adults.