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Clinical and Laboratory Findings of SARS-CoV-2 Infection in Children Younger than 6 Months Old: Neutropenia is More Common Not Lymphopenia.
Guner Ozenen, Gizem; Sahbudak Bal, Zumrut; Bilen, Nimet Melis; Yildirim Arslan, Sema; Ak, Gunes; Koc, Gonca; Cicek, Candan; Kurugol, Zafer; Ozkinay, Ferda.
  • Guner Ozenen G; Division of Infectious Disease, Department of Pediatrics, Medical School of Ege University, Izmir 35100, Turkey.
  • Sahbudak Bal Z; Division of Infectious Disease, Department of Pediatrics, Medical School of Ege University, Izmir 35100, Turkey.
  • Bilen NM; Division of Infectious Disease, Department of Pediatrics, Medical School of Ege University, Izmir 35100, Turkey.
  • Yildirim Arslan S; Division of Infectious Disease, Department of Pediatrics, Medical School of Ege University, Izmir 35100, Turkey.
  • Ak G; Department of Clinical Biochemistry, Medical School of Ege University, Izmir 35100, Turkey.
  • Koc G; Department of Radiology, Medical School of Ege University, Izmir 35100, Turkey.
  • Cicek C; Department of Microbiology and Infectious Diseases, Medical School of Ege University, Izmir 35100, Turkey.
  • Kurugol Z; Division of Infectious Disease, Department of Pediatrics, Medical School of Ege University, Izmir 35100, Turkey.
  • Ozkinay F; Division of Infectious Disease, Department of Pediatrics, Medical School of Ege University, Izmir 35100, Turkey.
J Trop Pediatr ; 68(3)2022 04 05.
Article in English | MEDLINE | ID: covidwho-1860907
ABSTRACT

BACKGROUND:

Studies on age-related differences in clinical and laboratory features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are limited. We aimed to evaluate the demographic, clinical, laboratory findings of SARS-CoV-2 infection in children younger than 6 months old and compare them with older children.

METHODS:

A single-center retrospective study, including 209 confirmed SARS-CoV-2 infection cases, was conducted between 11 March 2020 and 1 September 2021. The case group consisted of 47 patients younger than 6 months old, whereas the control group consisted of 162 patients older than 6 months old.

RESULTS:

The mean age of the case group was 2.77 ± 1.52 months, and the control group was 101.89 ± 65.77 months. Cough was statistically higher in the control group, and poor feeding was higher in the case group (p = 0.043, 0.010). The underlying disease rate was statistically higher in the control group; however, the hospitalization rate was higher in the case group (p = 0.036, 0.001). The case group had significantly lower median values of the absolute neutrophil count, hemoglobin and higher median values of white blood cell, absolute lymphocyte count and platelet than the control group (p < 0.05). C-reactive protein, fibrinogen values were significantly lower, and procalcitonin, D-dimer, troponin T, N-terminal pro-B-type natriuretic peptide significantly higher in the case group (p < 0.05). Lymphopenia was more common in the control group, whereas neutropenia was more common in the case group (p = 0.001, 0.011).

CONCLUSIONS:

We showed that most children younger than 6 months old had mild and asymptomatic SARS-CoV-2 infection; however, the hospitalization rate was higher, and neutropenia was more common in older children. Lay summaryStudies on age-related differences in clinical and laboratory features on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pediatric patients are limited. We aimed to evaluate the demographic, clinical and laboratory findings of SARS-CoV-2 infection in children younger than 6 months old and compare them with older children. A single-center retrospective study was conducted, including 209 SARS-CoV-2 infection cases. The case group consisted of 47 patients younger than 6 months old, and the control group consisted of 162 patients older than 6 months old. Most children younger than 6 months old had mild and asymptomatic SARS-CoV-2 infection; however, the hospitalization rate was higher than older children. Neutropenia was more common in patients younger than 6 months than older children with SARS-CoV-2 infection, even if underlying diseases were excluded.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Lymphopenia / Neutropenia Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Adolescent / Child / Humans / Infant Language: English Year: 2022 Document Type: Article Affiliation country: Tropej

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Lymphopenia / Neutropenia Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Adolescent / Child / Humans / Infant Language: English Year: 2022 Document Type: Article Affiliation country: Tropej