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Venous sinus thrombosis after the first dose of Pfizer BioNTech vaccine.
Qureshi, Muhammad Imran Ahmad; Azam, Bilal; Waheed, Muhammad Aamir; Imran, Afsheen.
  • Qureshi MIA; Acute Medicine/GIM, Northampton General Hospital NHS Trust, Northampton, UK mia.qureshi@nhs.net.
  • Azam B; Acute Internal Medicine, Northampton General Hospital NHS Trust, Northampton, UK.
  • Waheed MA; Acute Internal Medicine/GIM, Northampton General Hospital NHS Trust, Northampton, UK.
  • Imran A; General Internal Medicine, Northampton General Hospital NHS Trust, Northampton, UK.
BMJ Case Rep ; 15(5)2022 May 20.
Article in English | MEDLINE | ID: covidwho-1861598
ABSTRACT
mRNA vaccines including Pfizer BioNTech and Moderna have categorically been considered safe when it comes to preventing COVID-19. However, there is still a small associated risk of thromboembolic phenomenon including venous sinus thrombosis with it and our case report highlights one.We describe a patient who developed severe progressive headache, tinnitus and visual disturbance symptoms post-Pfizer-SARS-CoV-2 vaccination. His medical history included essential tremors, hypertension, type 2 diabetes mellitus, chronic kidney disease stage 3, anxiety, depression and long-term catheterisation. Systemic examination revealed hypotonia, generalised reduced power and central diplopia along with peripheral visual field defect in the left eye. He was extensively investigated, the COVID-19 PCR test was negative and all routine blood tests were in the normal range except a marginally raised D-dimer of 779 ng/mL. CT head was unremarkable. He was also tested for myasthenia gravis; however, acetylcholine receptors antibodies were negative and nerve conduction studies were normal. Subsequent MRI of the brain with venography confirmed venous sinus thrombosis. A 24-hour Holter monitoring test did not reveal any cardiac rate or rhythm abnormality. He was treated with apixaban as per a neurologist's advice. His clinical condition started to improve and was later discharged from the hospital with an outpatient neurologist clinic follow-up.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sinus Thrombosis, Intracranial / Diabetes Mellitus, Type 2 / COVID-19 / BNT162 Vaccine Type of study: Case report / Cohort study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans / Male Language: English Year: 2022 Document Type: Article Affiliation country: Bcr-2021-247493

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sinus Thrombosis, Intracranial / Diabetes Mellitus, Type 2 / COVID-19 / BNT162 Vaccine Type of study: Case report / Cohort study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans / Male Language: English Year: 2022 Document Type: Article Affiliation country: Bcr-2021-247493