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Lung Abnormalities Detected with Hyperpolarized 129Xe MRI in Patients with Long COVID.
Grist, James T; Collier, Guilhem J; Walters, Huw; Kim, Minsuok; Chen, Mitchell; Abu Eid, Gabriele; Laws, Aviana; Matthews, Violet; Jacob, Kenneth; Cross, Susan; Eves, Alexandra; Durrant, Marianne; McIntyre, Anthony; Thompson, Roger; Schulte, Rolf F; Raman, Betty; Robbins, Peter A; Wild, Jim M; Fraser, Emily; Gleeson, Fergus.
  • Grist JT; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Collier GJ; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Walters H; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Kim M; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Chen M; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Abu Eid G; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Laws A; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Matthews V; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Jacob K; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Cross S; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Eves A; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Durrant M; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • McIntyre A; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Thompson R; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Schulte RF; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Raman B; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Robbins PA; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Wild JM; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Fraser E; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
  • Gleeson F; From the Department of Radiology (J.T.G., H.W., M.C., G.A.E., A.L., V.M., K.J., S.C., A.E., M.D., A.M., F.G.) and Oxford Interstitial Lung Disease Service (E.F.), Oxford University Hospitals NHS Trust, Oxford, UK; Department of Physiology, Anatomy, and Genetics (J.T.G., P.A.R.), Radcliffe Department
Radiology ; 305(3): 709-717, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2138184
ABSTRACT
Background Post-COVID-19 condition encompasses symptoms following COVID-19 infection that linger at least 4 weeks after the end of active infection. Symptoms are wide ranging, but breathlessness is common. Purpose To determine if the previously described lung abnormalities seen on hyperpolarized (HP) pulmonary xenon 129 (129Xe) MRI scans in participants with post-COVID-19 condition who were hospitalized are also present in participants with post-COVID-19 condition who were not hospitalized. Materials and Methods In this prospective study, nonhospitalized participants with post-COVID-19 condition (NHLC) and posthospitalized participants with post-COVID-19 condition (PHC) were enrolled from June 2020 to August 2021. Participants underwent chest CT, HP 129Xe MRI, pulmonary function testing, and the 1-minute sit-to-stand test and completed breathlessness questionnaires. Control subjects underwent HP 129Xe MRI only. CT scans were analyzed for post-COVID-19 interstitial lung disease severity using a previously published scoring system and full-scale airway network (FAN) modeling. Analysis used group and pairwise comparisons between participants and control subjects and correlations between participant clinical and imaging data. Results A total of 11 NHLC participants (four men, seven women; mean age, 44 years ± 11 [SD]; 95% CI 37, 50) and 12 PHC participants (10 men, two women; mean age, 58 years ±10; 95% CI 52, 64) were included, with a significant difference in age between groups (P = .05). Mean time from infection was 287 days ± 79 (95% CI 240, 334) and 143 days ± 72 (95% CI 105, 190) in NHLC and PHC participants, respectively. NHLC and PHC participants had normal or near normal CT scans (mean, 0.3/25 ± 0.6 [95% CI 0, 0.63] and 7/25 ± 5 [95% CI 4, 10], respectively). Gas transfer (Dlco) was different between NHLC and PHC participants (mean Dlco, 76% ± 8 [95% CI 73, 83] vs 86% ± 8 [95% CI 80, 91], respectively; P = .04), but there was no evidence of other differences in lung function. Mean red blood cell-to-tissue plasma ratio was different between volunteers (mean, 0.45 ± 0.07; 95% CI 0.43, 0.47]) and PHC participants (mean, 0.31 ± 0.10; 95% CI 0.24, 0.37; P = .02) and between volunteers and NHLC participants (mean, 0.37 ± 0.10; 95% CI 0.31, 0.44; P = .03) but not between NHLC and PHC participants (P = .26). FAN results did not correlate with Dlco) or HP 129Xe MRI results. Conclusion Nonhospitalized participants with post-COVID-19 condition (NHLC) and posthospitalized participants with post-COVID-19 condition (PHC) showed hyperpolarized pulmonary xenon 129 MRI and red blood cell-to-tissue plasma abnormalities, with NHLC participants demonstrating lower gas transfer than PHC participants despite having normal CT findings. © RSNA, 2022 Online supplemental material is available for this article. See also the editorial by Parraga and Matheson in this issue.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Xenon Isotopes / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Radiology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Xenon Isotopes / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Radiology Year: 2022 Document Type: Article