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Post-vaccine COVID-19 in patients with multiple sclerosis or neuromyelitis optica.
Januel, Edouard; De Seze, Jérôme; Vermersch, Patrick; Maillart, Elisabeth; Bourre, Bertrand; Pique, Julie; Moisset, Xavier; Bensa, Caroline; Maarouf, Adil; Pelletier, Jean; Vukusic, Sandra; Audoin, Bertrand; Louapre, Céline.
  • Januel E; Assistance Publique des Hôpitaux de Paris, Hôpital de la Pitié Salpêtrière, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Neuroscience Clinical Investigation Center, Paris Brain Institute, Sorbonne Université, Paris, France.
  • De Seze J; Service de Neurologie and CIC INSERM 1434, CHU de Strasbourg, Strasbourg, France.
  • Vermersch P; Univ. Lille, Inserm UMR-S1172, CHU Lille, FHU Precise, Lille, France.
  • Maillart E; Assistance Publique des Hôpitaux de Paris, Hôpital de la Pitié Salpêtrière, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Neuroscience Clinical Investigation Center, Paris Brain Institute, Sorbonne Université, Paris, France.
  • Bourre B; Centre Hospitalier Universitaire Rouen Normandie, Hôpital Charles-Nicolle, Service de Neurologie, Rouen, France.
  • Pique J; Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France.
  • Moisset X; Department of Neurology, Neuro-Dol, CHU Clermont-Ferrand, Université Clermont Auvergne, INSERM U1107, Clermont-Ferrand, France.
  • Bensa C; Department of Neurology, Hôpital Fondation Adolphe de Rothschild, Paris, France.
  • Maarouf A; APHM, Hôpital de la Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Aix Marseille Univ, Marseille, France/Aix-Marseille University, CRMBM UMR 7339, CNRS, Marseille, France.
  • Pelletier J; APHM, Hôpital de la Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Aix Marseille Univ, Marseille, France/Aix-Marseille University, CRMBM UMR 7339, CNRS, Marseille, France.
  • Vukusic S; Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France.
  • Audoin B; APHM, Hôpital de la Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Aix Marseille Univ, Marseille, France/Aix-Marseille University, CRMBM UMR 7339, CNRS, Marseille, France.
  • Louapre C; Assistance Publique des Hôpitaux de Paris, Hôpital de la Pitié Salpêtrière, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Neuroscience Clinical Investigation Center, Paris Brain Institute, Sorbonne Université, Paris, France.
Mult Scler ; 28(7): 1155-1159, 2022 06.
Article in English | MEDLINE | ID: covidwho-1861991
ABSTRACT

INTRODUCTION:

Recent studies suggested that anti-CD20 and fingolimod may be associated with lower anti-spike protein-based immunoglobulin-G response following COVID-19 vaccination. We evaluated if COVID-19 occurred despite vaccination among patients with multiple sclerosis (MS) and neuromyelitis optica (NMO), using the COVISEP registry. CASE SERIES We report 18 cases of COVID-19 after two doses of BNT162b2-vaccination, 13 of which treated with anti-CD20 and four with fingolimod. COVID-19 severity was mild.

DISCUSSION:

These results reinforce the recommendation for a third COVID-19 vaccine dose among anti-CD20 treated patients and stress the need for a prospective clinical and biological study on COVID-19 vaccine efficacy among MS and NMO patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuromyelitis Optica / COVID-19 / BNT162 Vaccine / Multiple Sclerosis Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Mult Scler Journal subject: Neurology Year: 2022 Document Type: Article Affiliation country: 13524585211049737

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuromyelitis Optica / COVID-19 / BNT162 Vaccine / Multiple Sclerosis Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Mult Scler Journal subject: Neurology Year: 2022 Document Type: Article Affiliation country: 13524585211049737