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Blood Pressure Increase following COVID-19 Vaccination: A Systematic Overview and Meta-Analysis.
Angeli, Fabio; Reboldi, Gianpaolo; Trapasso, Monica; Santilli, Gabriella; Zappa, Martina; Verdecchia, Paolo.
  • Angeli F; Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.
  • Reboldi G; Department of Medicine and Cardiopulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, 21049 Tradate, Italy.
  • Trapasso M; Department of Medicine, and Centro di Ricerca Clinica e Traslazionale (CERICLET), University of Perugia, 06100 Perugia, Italy.
  • Santilli G; Dipartimento di Igiene e Prevenzione Sanitaria, PSAL, Sede Territoriale di Varese, ATS Insubria, 21100 Varese, Italy.
  • Zappa M; Department of Medicine, and Centro di Ricerca Clinica e Traslazionale (CERICLET), University of Perugia, 06100 Perugia, Italy.
  • Verdecchia P; Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.
J Cardiovasc Dev Dis ; 9(5)2022 May 09.
Article in English | MEDLINE | ID: covidwho-1862817
ABSTRACT
Coronavirus disease 2019 (COVID-19) vaccines proved a strong clinical efficacy against symptomatic or moderate/severe COVID-19 and are considered the most promising approach for curbing the pandemic. However, some questions regarding the safety of COVID-19 vaccines have been recently raised. Among adverse events to vaccines and despite a lack of signal during phase III clinical trials, an increase in blood pressure (BP) after COVID-19 vaccination has been reported as a potential adverse reaction. We systematically analyze this topic and undertook a meta-analysis of available data to estimate the proportion of patients with abnormal BP or raise in BP after vaccination. Six studies entered the final analysis. Overall, studies accrued 357,387 subjects with 13,444 events of abnormal or increased BP. After exclusion of outlier studies, the pooled estimated proportion of abnormal/increased BP after vaccination was 3.20% (95% CI 1.62-6.21). Proportions of cases of stage III hypertension or hypertensive urgencies and emergencies was 0.6% (95% CI 0.1% to 5.1%). In conclusion, abnormal BP is not rare after COVID-19 vaccination, but the basic mechanisms of this phenomenon are still unclear and require further research.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Jcdd9050150

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Jcdd9050150