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The Multifaceted Manifestations of Multisystem Inflammatory Syndrome during the SARS-CoV-2 Pandemic.
Pérez-Gómez, Héctor Raúl; Morfín-Otero, Rayo; González-Díaz, Esteban; Esparza-Ahumada, Sergio; León-Garnica, Gerardo; Rodríguez-Noriega, Eduardo.
  • Pérez-Gómez HR; Centro Universitario Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.
  • Morfín-Otero R; Instituto de Patología Infecciosa y Experimental, Centro Universitario Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44280, Jalisco, Mexico.
  • González-Díaz E; Centro Universitario Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.
  • Esparza-Ahumada S; Instituto de Patología Infecciosa y Experimental, Centro Universitario Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44280, Jalisco, Mexico.
  • León-Garnica G; Centro Universitario Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.
  • Rodríguez-Noriega E; Instituto de Patología Infecciosa y Experimental, Centro Universitario Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44280, Jalisco, Mexico.
Pathogens ; 11(5)2022 May 08.
Article in English | MEDLINE | ID: covidwho-1862869
ABSTRACT
The novel coronavirus SARS-CoV-2, which has similarities to the 2002-2003 severe acute respiratory syndrome coronavirus known as SARS-CoV-1, causes the infectious disease designated COVID-19 by the World Health Organization (Coronavirus Disease 2019). Although the first reports indicated that activity of the virus is centered in the lungs, it was soon acknowledged that SARS-CoV-2 causes a multisystem disease. Indeed, this new pathogen causes a variety of syndromes, including asymptomatic disease; mild disease; moderate disease; a severe form that requires hospitalization, intensive care, and mechanical ventilation; multisystem inflammatory disease; and a condition called long COVID or postacute sequelae of SARS-CoV-2 infection. Some of these syndromes resemble previously described disorders, including those with no confirmed etiology, such as Kawasaki disease. After recognition of a distinct multisystem inflammatory syndrome in children, followed by a similar syndrome in adults, various multisystem syndromes occurring during the pandemic associated or related to SARS-CoV-2 began to be identified. A typical pattern of cytokine and chemokine dysregulation occurs in these complex syndromes; however, the disorders have distinct immunological determinants that may help to differentiate them. This review discusses the origins of the different trajectories of the inflammatory syndromes related to SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study Topics: Long Covid Language: English Year: 2022 Document Type: Article Affiliation country: Pathogens11050556

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study Topics: Long Covid Language: English Year: 2022 Document Type: Article Affiliation country: Pathogens11050556