HYSSOP and POLIUM could help to prevent COVID-19 in high-risk population: the results of a parallel randomized placebo-controlled field trial
Indian Journal of Traditional Knowledge
; 21(2):243-253, 2022.
Article
in English
| CAB Abstracts | ID: covidwho-1863903
ABSTRACT
This study was conducted to evaluate the effect of HYSSOP (composed of Hyssopus officinalis L., Echium amoenum Fisch & C. A. Mey and Glycyrrhiza glabra L.) and POLIUM (contained Teucrium polium L., Cuscuta epithymum Murr and Cichorium intybus L.) combined distilled herbal medicines compared to placebo in the prevention of COVID-19. This is a double-blind parallel placebo-controlled field trial conducted on 751 asymptomatic individuals whose one of the family members recently had a positive RT-PCR test for COVID-19. They were divided into three groups including POLIUM, HYSSOP and placebo using random blocks with a 111 allocation ratio. Participants received daily 5 cc (under 12 years) or 10 cc (over 12 years) of allocated oral medications for 20 days. The primary outcome was the frequency of positive RT-PCR test among participants who became symptomatic. The mean age of participants was 36.6. Nineteen participants get infected by COVID-19 during the intervention;fifteen of them belonged to the placebo and four to the POLIUM group. Fisher's exact test indicated significant differences between HYSSOP and placebo (p<0.001) as well as POLIUM and placebo (p=0.009) groups in terms of COVID-19 confirmed by PCR tests. Cox regression model adjusted for confounders illustrated that the hazard of getting infection by COVID-19 in POLIUM and HYSSOP groups decreased by 66% (OR (95% CI) 0.34 (0.12 to 0.94);p=0.038) and 93% (OR (95% CI) 0.07 (0.01to 0.56);p=0.012) respectively, compared to placebo. Oral administration of HYSSOP and POLIUM with the other supportive health care could decrease the risk of getting COVID-19.
Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Pesticides and Drugs; Control [HH405]; Pharmacology [VV730]; Non-food/Non-feed Plant Products [SS200]; human diseases; viral diseases; coronavirus disease 2019; risk factors; randomized controlled trials; clinical trials; health care; herbal drugs; medicinal plants; parasitic plants; polymerase chain reaction; traditional medicines; liquorice; chicory; antiviral properties; plant parasites; man; Severe acute respiratory syndrome coronavirus 2; Hyssopus officinalis; Cichorium intybus; Cuscuta epithymum; Echium; Glycyrrhiza glabra; Teucrium polium; plants; Glycyrrhiza; Iran; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; high Human Development Index countries; lower-middle income countries; Middle East; West Asia; Asia; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Hyssopus (Spermatophyta); Lamiaceae; Lamiales; eudicots; angiosperms; Spermatophyta; Cichorium; Asteraceae; Asterales; Cuscuta; Convolvulaceae; Solanales; Boraginaceae; Boraginales; Papilionoideae; Fabaceae; Fabales; Teucrium; Echium amoenum; SARS-CoV-2; viral infections; herbal medicines; drug plants; medicinal herbs; officinal plants; PCR; licorice; anti-viral properties
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Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Language:
English
Journal:
Indian Journal of Traditional Knowledge
Year:
2022
Document Type:
Article
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