Your browser doesn't support javascript.
Humoral immune response to authentic circulating severe acute respiratory syndrome coronavirus 2 variants elicited by booster vaccination with distinct receptor-binding domain subunits in mice.
Jiang, Yushan; Zhang, Huan; Yu, Jianhai; Huang, Dong; Zhai, Linlin; Li, Mengjun; Wang, Yuelin; Ren, Zuning; Zou, Lirong; Zheng, Zhonghua; Hu, Huanyu; Zhang, Junfang; Zhang, Bao; Zhao, Wei; Yang, Xingfen; Li, Baisheng; Shen, Chenguang.
  • Jiang Y; BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
  • Zhang H; Provincial Center for Disease Control and Prevention, Guangzhou, China.
  • Yu J; BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
  • Huang D; BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
  • Zhai L; BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
  • Li M; BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
  • Wang Y; BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
  • Ren Z; BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
  • Zou L; Provincial Center for Disease Control and Prevention, Guangzhou, China.
  • Zheng Z; Provincial Center for Disease Control and Prevention, Guangzhou, China.
  • Hu H; BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
  • Zhang J; Shenzhen Immuthy Biotech Co., Ltd, Shenzhen, China.
  • Zhang B; BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
  • Zhao W; BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
  • Yang X; BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
  • Li B; Provincial Center for Disease Control and Prevention, Guangzhou, China.
  • Shen C; BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
J Med Virol ; 94(9): 4533-4538, 2022 09.
Article in English | MEDLINE | ID: covidwho-1885414
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants could induce immune escape by mutations of the spike protein which are threatening to weaken vaccine efficacy. A booster vaccination is expected to increase the humoral immune response against SARS-CoV-2 variants in the population. We showed that immunization with two doses of wild type receptor-binding domain (RBD) protein, and booster vaccination with wild type or variant RBD protein all significantly increased binding and neutralizing antibody titers against wild type SARS-CoV-2 and its variants in mice. Only the booster immunization by Omicron (BA.1)RBD induced a strong antibody titer against the omicron virus strain and comparable antibody titers against all the other virus strains. These findings might shed the light on coronavirus disease 2019 booster immunogens.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunity, Humoral / COVID-19 Vaccines / COVID-19 Topics: Vaccines / Variants Limits: Animals / Humans Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27882

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunity, Humoral / COVID-19 Vaccines / COVID-19 Topics: Vaccines / Variants Limits: Animals / Humans Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27882