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Bacteremia in Children with Solid Tumors: Etiology, Antimicrobial Susceptibility, Factors Associated with Multidrug Resistance, and Mortality.
Ginzburg, Amit; Goldstein, Gal; Raviv, Dror; Cohen, Hodaya; Weinreb, Sigal; Harlev, Dan; Nitsan-Luques, Adi; Abou Saoud, Mohammad Yacoub; Strahilevitz, Jacob; Averbuch, Diana.
  • Ginzburg A; Pediatric Infectious Diseases Unit, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel.
  • Goldstein G; The Dyna & Fala Weinstock Department of Pediatric Hematology Oncology, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel.
  • Raviv D; The Dyna & Fala Weinstock Department of Pediatric Hematology Oncology, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel.
  • Cohen H; The Dyna & Fala Weinstock Department of Pediatric Hematology Oncology, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel.
  • Weinreb S; The Dyna & Fala Weinstock Department of Pediatric Hematology Oncology, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel.
  • Harlev D; The Dyna & Fala Weinstock Department of Pediatric Hematology Oncology, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel.
  • Nitsan-Luques A; The Dyna & Fala Weinstock Department of Pediatric Hematology Oncology, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel.
  • Abou Saoud MY; The Dyna & Fala Weinstock Department of Pediatric Hematology Oncology, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel.
  • Strahilevitz J; Department of Clinical Microbiology and Infectious Diseases, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel.
  • Averbuch D; Pediatric Infectious Diseases Unit, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Israel.
Microb Drug Resist ; 28(5): 601-610, 2022 May.
Article in English | MEDLINE | ID: covidwho-1864944
ABSTRACT
This retrospective study aims to describe the etiology and resistance patterns of pathogens causing bacteremia in children with solid tumors in a tertiary pediatric hematology-oncology center in Jerusalem, Israel (2011-2019). Factors associated with multidrug-resistant (MDR) bacteremia and mortality were analyzed. A total of 228 pathogens were isolated in 126 patients; 61.0% were gram-negative rods (GNR) and 38.2% were gram-positive cocci (GPC). The most common pathogens were Klebsiella pneumoniae (19.3%), Escherichia coli (17.5%), and coagulase-negative staphylococci (16.2%). The proportion of MDR-GNR was 18.2%, while the proportion of MDR-GPC was 55.2%. In logistic regression analysis, breakthrough bacteremia on a penicillin-group antibiotic (odds ratio [OR] 5.69, [95% confidence interval 1.42-22.76], p-value = 0.014) was associated and underlying diagnosis of neuroblastoma was inversely associated (OR 0.17, [0.04-0.81], p-value = 0.026) with MDR-GNR bacteremia; while the previous hospitalizations' duration (OR 1.032/day, [1.01-1.06], p-value = 0.007) and oncologic treatment intensity (OR 2.19, [1.08-4.45, p-value = 0.03) were associated with MDR-GPC bacteremia. Shock, prolonged profound neutropenia, and pediatric intensive care unit (PICU) admission were associated with 7-day mortality; and relapsed disease, oncologic treatment intensity, prolonged profound neutropenia, and PICU admission-with 30-day mortality in the univariate analyses. Empirical antibiotic choice should be based on factors associated with MDR infections in this specific population.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gram-Negative Bacterial Infections / Bacteremia / Neoplasms / Neutropenia Type of study: Etiology study / Observational study / Prognostic study Topics: Long Covid Limits: Child / Humans Language: English Journal: Microb Drug Resist Journal subject: Microbiology / Drug Therapy Year: 2022 Document Type: Article Affiliation country: Mdr.2021.0256

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gram-Negative Bacterial Infections / Bacteremia / Neoplasms / Neutropenia Type of study: Etiology study / Observational study / Prognostic study Topics: Long Covid Limits: Child / Humans Language: English Journal: Microb Drug Resist Journal subject: Microbiology / Drug Therapy Year: 2022 Document Type: Article Affiliation country: Mdr.2021.0256