Investigation on the impact of potential phytocompounds from Curcuma longa against COVID-19
Journal of Plant Sciences
; 17(1):33-52, 2022.
Article
in English
| CAB Abstracts | ID: covidwho-1865588
ABSTRACT
Background and Objective:
COVID-19 is a new viral infectious disease caused by SARS-CoV-2 and there are no vaccines or drugs available to treat this deadly disease. Curcuma longa is a well-known medicinal plant with the antiviral property. So, the present study aims to evaluate the antiviral activity of phytocompounds from Curcuma longa against SARS-CoV-2. Materials andMethods:
The phytocompounds from the Curcuma longa were docked with the main protease of SARS-CoV-2 (SARS-CoV-2 Mpro) by Autodock 4.2 to analyze the possibility of inhibiting the SARS-CoV-2 Mpro. Protein-ligand interaction profiler and ligplot+v.1.4.5 were used to analyze the interactions between the ligand and protein molecules. The toxicity and pharmacophore of the phytocompounds were determined by SWISSADME and PharmaGist web server.
Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Non-food/Non-feed Plant Products [SS200]; Animal and in vitro Models for Pharmaceuticals [VV450]; Pesticides and Drugs; Control [HH405]; medicinal plants; plant extracts; coronavirus disease 2019; antiviral properties; beta-carotene; enzymes; interactions; plant composition; proteinases; toxicity; traditional medicines; turmeric; ligands; hydrogen bonding; rhizomes; pathogens; Severe acute respiratory syndrome coronavirus 2; Curcuma longa; plants; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Curcuma; Zingiberaceae; Zingiberales; commelinids; monocotyledons; angiosperms; Spermatophyta; eukaryotes; drug plants; medicinal herbs; officinal plants; SARS-CoV-2; anti-viral properties; chemical constituents of plants; proteases
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Experimental Studies
Language:
English
Journal:
Journal of Plant Sciences
Year:
2022
Document Type:
Article
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