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Study protocol for the St James's Hospital, Tallaght University Hospital, Trinity College Dublin Allied Researchers' (STTAR) Bioresource for COVID-19.
O'Doherty, Laura; Hendricken Phelan, Stuart; Wood, Nicole; O'Brien, Sorcha; Sui, Jacklyn; Mangan, Cian; Howley, Fergal; O'Regan, Siobhan; Razif, Noor Adeebah Mohamed; Conlan, Ciara; Argue, Ruth; Holohan, Samuel; Dyer, Adam; Salleh, Fara; Townsend, Liam; Hughes, Gerard; Kerr, Colm; Reidy, Derval; Sanz, Alberto; Connolly, Emma; Kelly, Andrea; Leacy, Emma; Reddy, Conor; Gargan, Siobhan; Breen, Eamon; Hawerkamp, Heike; Dunne, Jean; Martin-Loeches, Ignacio; McLaughlin, Anne Marie; Long, Aideen; Shiels, Orla; Fallon, Padraic; Hennessy, Martina; Romero-Ortuno, Roman; Bannan, Ciaran; Prior, Anna Rose; Rakovac, Ana; McCormack, William; McManus, Ross; Donnelly, Seamus; Bergin, Colm; Little, Mark; Ní Cheallaigh, Clíona; Conlon, Niall.
  • O'Doherty L; Department of Infectious Diseases, St. James's Hospital, Dublin, Dublin, Ireland.
  • Hendricken Phelan S; Clinical Research Facility, St. James's Hospital, Dublin, Dublin, Ireland.
  • Wood N; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • O'Brien S; Clinical Research Facility, St. James's Hospital, Dublin, Dublin, Ireland.
  • Sui J; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Mangan C; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Howley F; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • O'Regan S; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Razif NAM; Department of Immunology, St James's Hospital, Dublin, Ireland.
  • Conlan C; Clinical Research Facility, St. James's Hospital, Dublin, Dublin, Ireland.
  • Argue R; Department of Infectious Diseases, St. James's Hospital, Dublin, Dublin, Ireland.
  • Holohan S; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Dyer A; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Salleh F; Clinical Research Facility, St. James's Hospital, Dublin, Dublin, Ireland.
  • Townsend L; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Hughes G; Clinical Research Facility, St. James's Hospital, Dublin, Dublin, Ireland.
  • Kerr C; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Reidy D; Clinical Research Facility, St. James's Hospital, Dublin, Dublin, Ireland.
  • Sanz A; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Connolly E; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Kelly A; Department of Infectious Diseases, St. James's Hospital, Dublin, Dublin, Ireland.
  • Leacy E; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Reddy C; Department of Infectious Diseases, St. James's Hospital, Dublin, Dublin, Ireland.
  • Gargan S; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Breen E; Department of Infectious Diseases, St. James's Hospital, Dublin, Dublin, Ireland.
  • Hawerkamp H; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Dunne J; Clinical Research Facility, St. James's Hospital, Dublin, Dublin, Ireland.
  • Martin-Loeches I; Clinical Research Facility, St. James's Hospital, Dublin, Dublin, Ireland.
  • McLaughlin AM; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Long A; Clinical Research Facility, St. James's Hospital, Dublin, Dublin, Ireland.
  • Shiels O; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Fallon P; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Hennessy M; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Romero-Ortuno R; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Bannan C; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Prior AR; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Rakovac A; Department of Immunology, St James's Hospital, Dublin, Ireland.
  • McCormack W; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • McManus R; Department of Intensive Care Medicine, St James's Hospital, Dublin, Ireland.
  • Donnelly S; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Bergin C; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Little M; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Ní Cheallaigh C; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Conlon N; Clinical Research Facility, St. James's Hospital, Dublin, Dublin, Ireland.
HRB Open Res ; 5: 20, 2022.
Article in English | MEDLINE | ID: covidwho-1865656
ABSTRACT

Background:

The current coronavirus disease 2019 (COVID-19) pandemic began in Ireland with the first confirmed positive case in March 2020. In the early stages of the pandemic clinicians and researchers in two affiliated Dublin hospitals identified the need for a COVID-19 biobanking initiative to support and enhance research into the disease. Through large scale analysis of clinical, regional, and genetic characteristics of COVID-19 patients, biobanks have helped identify, and so protect, at risk patient groups The STTAR Bioresource has been created to collect and store data and linked biological samples from patients with SARS-CoV-2 infection and healthy and disease controls.

Aim:

The primary objective of this study is to build a biobank, to understand the clinical characteristics and natural history of COVID-19 infection with the long-term goal of research into improved disease understanding, diagnostic tests and treatments.

Methods:

This is a prospective dual-site cohort study across two tertiary acute university teaching hospitals. Patients are recruited from inpatient wards or outpatient clinics. Patients with confirmed COVID-19 infection as well as healthy and specific disease control groups are recruited.  Biological samples are collected and a case report form detailing demographic and medical background is entered into the bespoke secure online Dendrite database. Impact The results of this study will be used to inform national and international strategy on health service provision and disease management related to COVID-19. In common with other biobanks, study end points  evolve over time as new research questions emerge. They currently include patient survival, occurrence of severe complications of the disease or its therapy, occurrence of persistent symptoms following recovery from the acute illness and vaccine responses.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Language: English Journal: HRB Open Res Year: 2022 Document Type: Article Affiliation country: Hrbopenres.13498.1

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Language: English Journal: HRB Open Res Year: 2022 Document Type: Article Affiliation country: Hrbopenres.13498.1