Procalcitonin/Albumin Ratio as a Novel Biomarker for Predicting Mortality in COVID-19
Journal of Pioneering Medical Sciences
; 11(1):3-7, 2022.
Article
in English
| EMBASE | ID: covidwho-1912975
ABSTRACT
Background:
Coronavirus disease 2019 (COVID-19) first appeared in China in December 2019, and has become a global pandemic. Because the clinical progression of the disease is highly variable, better prediction of prognosis and mortality is important. In the present study, we investigated the role of procalcitonin/albumin ratio (PAR) as a new biomarker in predicting mortality in patients with COVID-19 infection.Methods:
In this study, patients with COVID-19 diagnosis were enrolled from Sakarya Yenikent State Hospital and Ayancık State Hospital between 09.11.2020 and 04.05.2021. The demographic characteristics, biochemical and hematological parameters such as age, gender, length of hospital stay, and comorbidities of the patients were collected retrospectively from medical records.Results:
Of the 105 patients, 51 were mild and 54 were critically ill. Between mild and critical cases, age, lymphocyte count, red cell distribution width, neutrophile count, mean corpuscular volume (MCV), monocyte count, albumin, C-reactive protein, ferritin, procalcitonin, D-dimer, and PAR were statistically different (p<0.001 for all). All patients in the critical group and only 2% of the mild group died. PAR showed the largest area under the curve (0.949) for the prediction of mortality (p<0.001).Conclusion:
We report that PAR, a simple, cheap, and easily accessible biomarker, can be used to predict the prognosis in patients with COVID-19 infection.
albumin; aspartate aminotransferase; C reactive protein; D dimer; ferritin; lactate dehydrogenase; procalcitonin; urea; adult; albumin blood level; article; aspartate aminotransferase blood level; biochemical analysis; blood analysis; cellular distribution; comorbidity; controlled study; coronavirus disease 2019; critically ill patient; demographics; diagnostic accuracy; diagnostic value; female; ferritin blood level; hematological parameters; hospitalization; human; lactate dehydrogenase blood level; length of stay; leukocyte count; lymphocyte count; major clinical study; male; mean corpuscular volume; mean platelet volume; medical record; monocyte count; mortality; mortality risk; neutrophil count; plateletcrit; prediction; procalcitonin albumin ratio; protein blood level; receiver operating characteristic; retrospective study; risk factor; sensitivity and specificity; urea blood level
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Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Language:
English
Journal:
Journal of Pioneering Medical Sciences
Year:
2022
Document Type:
Article
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