Nasal immunization and research progress of the development of COVID-19 vaccine

ABSTRACT

The appropriate immune pathway is the key to induce effective immune protection. Compared with traditional invasive immunization methods such as intramuscular injection and subcutaneous injection, nasal immunization has the advantages of convenient use, high compliance of vaccinators and induction of more comprehensive immune response, thus has attracted the attention of researchers in the epidemic of COVID-19. This paper briefly introduces the mechanism and characteristics of nasal immunization, summarizes the COVID-19 vaccine products and technology platforms regarding nasal immunization, so as to provide reference for related research and development work.