Mammalian viral suppressors of RNA interference.
Trends Biochem Sci
; 47(11): 978-988, 2022 11.
Article
in English
| MEDLINE | ID: covidwho-1866217
ABSTRACT
The antiviral defense directed by the RNAi pathway employs distinct specificity and effector mechanisms compared with other immune responses. The specificity of antiviral RNAi is programmed by siRNAs processed from virus-derived double-stranded RNA by Dicer endonuclease. Argonaute-containing RNA-induced silencing complex loaded with the viral siRNAs acts as the effector to mediate specific virus clearance by RNAi. Recent studies have provided evidence for the production and antiviral function of virus-derived siRNAs in both undifferentiated and differentiated mammalian cells infected with a range of RNA viruses when the cognate virus-encoded suppressor of RNAi (VSR) is rendered nonfunctional. In this review, we discuss the function, mechanism, and evolutionary origin of the validated mammalian VSRs and cell culture assays for their identification.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
RNA, Double-Stranded
/
Argonaute Proteins
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Trends Biochem Sci
Year:
2022
Document Type:
Article
Affiliation country:
J.tibs.2022.05.001
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