Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?

Grimm, Christian; Tang, Rachel

Grimm, Christian; Tang, Rachel.

Grimm C; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany.
Tang R; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany.

Cell Calcium ; 88: 102212, 2020 06.

Article in English | MEDLINE | ID: covidwho-186635

ABSTRACT

ABSTRACT

The ongoing SARS-CoV2 outbreak has developed into a global pandemic. Despite previous outbreaks of SARS-CoV and the related MERS-CoV in recent years, neither a vaccine nor any other medication for an effective treatment are currently available. Endo-lysosomal two-pore cation channels have now emerged as potential novel targets for SARS-CoV treatment.

Subject(s)

Betacoronavirus/metabolism; Coronavirus Infections/metabolism; Ion Channels/antagonists & inhibitors; Ion Channels/metabolism; Lysosomes/metabolism; Pneumonia, Viral/metabolism; Animals; Betacoronavirus/drug effects; COVID-19; Calcium Channel Blockers/pharmacology; Calcium Channel Blockers/therapeutic use; Calcium Channels/metabolism; Coronavirus Infections/drug therapy; Humans; Lysosomes/drug effects; Middle East Respiratory Syndrome Coronavirus/drug effects; Middle East Respiratory Syndrome Coronavirus/metabolism; Pandemics; Pneumonia, Viral/drug therapy; Protein Transport/drug effects; Protein Transport/physiology; SARS-CoV-2; Severe Acute Respiratory Syndrome/drug therapy; Severe Acute Respiratory Syndrome/metabolism

Keywords

Covid-19; Lysosome; SARS-CoV2; TPC; TPC2; Two-pore channel

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Ion Channels / Lysosomes Topics: Vaccines Limits: Animals / Humans Language: English Journal: Cell Calcium Year: 2020 Document Type: Article Affiliation country: J.ceca.2020.102212

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