Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses.
Cancer Cell
; 40(7): 738-753.e5, 2022 07 11.
Article
in English
| MEDLINE | ID: covidwho-1866941
ABSTRACT
How immune dysregulation affects recovery from COVID-19 infection in patients with cancer remains unclear. We analyzed cellular and humoral immune responses in 103 patients with prior COVID-19 infection, more than 20% of whom had delayed viral clearance. Delayed clearance was associated with loss of antibodies to nucleocapsid and spike proteins with a compensatory increase in functional T cell responses. High-dimensional analysis of peripheral blood samples demonstrated increased CD8+ effector T cell differentiation and a broad but poorly converged COVID-specific T cell receptor (TCR) repertoire in patients with prolonged disease. Conversely, patients with a CD4+ dominant immunophenotype had a lower incidence of prolonged disease and exhibited a deep and highly select COVID-associated TCR repertoire, consistent with effective viral clearance and development of T cell memory. These results highlight the importance of B cells and CD4+ T cells in promoting durable SARS-CoV-2 clearance and the significance of coordinated cellular and humoral immunity for long-term disease control.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Cancer Cell
Journal subject:
Neoplasms
Year:
2022
Document Type:
Article
Affiliation country:
J.ccell.2022.05.013
Similar
MEDLINE
...
LILACS
LIS