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TNF-related apoptosis-inducing ligand, interferon gamma-induced protein 10, and C-reactive protein in predicting the progression of SARS-CoV-2 infection: a prospective cohort study.
Tegethoff, Sina A; Danziger, Guy; Kühn, Dennis; Kimmer, Charlotte; Adams, Thomas; Heintz, Lena; Metz, Carlos; Reifenrath, Katharina; Angresius, Rebecca; Mang, Sebastian; Rixecker, Torben; Becker, André; Geisel, Jürgen; Jentgen, Christophe; Seiler, Frederik; Reichert, Matthias C; Fröhlich, Franziska; Meyer, Sascha; Rissland, Jürgen; Ewen, Sebastian; Wagenpfeil, Gudrun; Last, Katharina; Smola, Sigrun; Bals, Robert; Lammert, Frank; Becker, Sören L; Krawczyk, Marcin; Lepper, Philipp M; Papan, Cihan.
  • Tegethoff SA; Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany.
  • Danziger G; Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Kühn D; Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany; Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Kimmer C; Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany.
  • Adams T; Department of Medicine II, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Heintz L; Department of Medicine II, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Metz C; Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Reifenrath K; Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany; Department of Medicine II, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Angresius R; Department of Medicine II, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Mang S; Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Rixecker T; Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Becker A; Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Geisel J; Department of Clinical Chemistry and Laboratory Medicine, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Jentgen C; Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Seiler F; Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Reichert MC; Department of Medicine II, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Fröhlich F; Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany; Department of General Paediatrics and Neonatology, Saarland University, Homburg, Germany.
  • Meyer S; Department of General Paediatrics and Neonatology, Saarland University, Homburg, Germany.
  • Rissland J; Centre for Infectious Diseases, Institute of Virology, Saarland University Medical Centre, Homburg, Germany.
  • Ewen S; Department of Emergency Medicine, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Wagenpfeil G; Institute of Medical Biometry, Epidemiology and Medical Informatics, Saarland University, Homburg, Germany.
  • Last K; Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany.
  • Smola S; Centre for Infectious Diseases, Institute of Virology, Saarland University Medical Centre, Homburg, Germany; Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, Saarland University Campus, Saarbrücken, Germany.
  • Bals R; Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Lammert F; Department of Medicine II, Saarland University Medical Centre, Saarland University, Homburg, Germany; Hannover Medical School (MHH), Hannover, Germany.
  • Becker SL; Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany.
  • Krawczyk M; Department of Medicine II, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Lepper PM; Department of Medicine V: Pneumology, Allergology and Intensive Care Medicine, ECLS Centre Saar, Saarland University Medical Centre, Saarland University, Homburg, Germany.
  • Papan C; Centre for Infectious Diseases, Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany. Electronic address: cihan.papan@uks.eu.
Int J Infect Dis ; 122: 178-187, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-1889494
ABSTRACT

BACKGROUND:

Early prognostication of COVID-19 severity will potentially improve patient care. Biomarkers, such as TNF-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein 10 (IP-10), and C-reactive protein (CRP), might represent possible tools for point-of-care testing and severity prediction.

METHODS:

In this prospective cohort study, we analyzed serum levels of TRAIL, IP-10, and CRP in patients with COVID-19, compared them with control subjects, and investigated the association with disease severity.

RESULTS:

A total of 899 measurements were performed in 132 patients (mean age 64 years, 40.2% females). Among patients with COVID-19, TRAIL levels were lower (49.5 vs 87 pg/ml, P = 0.0142), whereas IP-10 and CRP showed higher levels (667.5 vs 127 pg/ml, P <0.001; 75.3 vs 1.6 mg/l, P <0.001) than healthy controls. TRAIL yielded an inverse correlation with length of hospital and intensive care unit (ICU) stay, Simplified Acute Physiology Score II, and National Early Warning Score, and IP-10 showed a positive correlation with disease severity. Multivariable regression revealed that obesity (adjusted odds ratio [aOR] 5.434, 95% confidence interval [CI] 1.005-29.38), CRP (aOR 1.014, 95% CI 1.002-1.027), and peak IP-10 (aOR 1.001, 95% CI 1.00-1.002) were independent predictors of in-ICU mortality.

CONCLUSIONS:

We demonstrated a correlation between COVID-19 severity and TRAIL, IP-10, and CRP. Multivariable regression showed a role for IP-10 in predicting unfavourable outcomes, such as in-ICU mortality. TRIAL REGISTRATION Clinicaltrials.gov, NCT04655521.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: C-Reactive Protein / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Male / Middle aged Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.ijid.2022.05.051

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Full text: Available Collection: International databases Database: MEDLINE Main subject: C-Reactive Protein / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Male / Middle aged Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.ijid.2022.05.051