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Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C.
Tang, Juanjie; Novak, Tanya; Hecker, Julian; Grubbs, Gabrielle; Zahra, Fatema Tuz; Bellusci, Lorenza; Pourhashemi, Sara; Chou, Janet; Moffitt, Kristin; Halasa, Natasha B; Schwartz, Stephanie P; Walker, Tracie C; Tarquinio, Keiko M; Zinter, Matt S; Staat, Mary A; Gertz, Shira J; Cvijanovich, Natalie Z; Schuster, Jennifer E; Loftis, Laura L; Coates, Bria M; Mack, Elizabeth H; Irby, Katherine; Fitzgerald, Julie C; Rowan, Courtney M; Kong, Michele; Flori, Heidi R; Maddux, Aline B; Shein, Steven L; Crandall, Hillary; Hume, Janet R; Hobbs, Charlotte V; Tremoulet, Adriana H; Shimizu, Chisato; Burns, Jane C; Chen, Sabrina R; Moon, Hye Kyung; Lange, Christoph; Randolph, Adrienne G; Khurana, Surender.
  • Tang J; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA.
  • Novak T; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
  • Hecker J; Department of Anesthesia, Harvard Medical School, Boston, MA, 02115, USA.
  • Grubbs G; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
  • Zahra FT; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA.
  • Bellusci L; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA.
  • Pourhashemi S; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA.
  • Chou J; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA.
  • Moffitt K; Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
  • Halasa NB; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
  • Schwartz SP; Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
  • Walker TC; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, 02115, USA.
  • Tarquinio KM; Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
  • Zinter MS; Department of Pediatrics, University of North Carolina at Chapel Hill Children's Hospital, Chapel Hill, NC, 27514, USA.
  • Staat MA; Department of Pediatrics, University of North Carolina at Chapel Hill Children's Hospital, Chapel Hill, NC, 27514, USA.
  • Gertz SJ; Division of Critical Care Medicine, Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA, 30322, USA.
  • Cvijanovich NZ; Department of Pediatrics, Divisions of Critical Care and Bone Marrow Transplantation, University of California, San Francisco, San Francisco, CA, 94158, USA.
  • Schuster JE; Department of Pediatrics, University of Cincinnati, Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
  • Loftis LL; Division of Pediatric Critical Care, Department of Pediatrics, Cooperman Barnabas Medical Center, Livingston, NJ, 07039, USA.
  • Coates BM; Division of Critical Care Medicine, UCSF Benioff Children's Hospital Oakland, Oakland, CA, 94609, USA.
  • Mack EH; Division of Pediatric Infectious Diseases, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, MO, 64108, USA.
  • Irby K; Division of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX, 77030, USA.
  • Fitzgerald JC; Division of Critical Care Medicine, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA.
  • Rowan CM; Division of Pediatric Critical Care Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.
  • Kong M; Section of Pediatric Critical Care, Department of Pediatrics, Arkansas Children's Hospital, Little Rock, AR, 72202, USA.
  • Flori HR; Division of Critical Care, Department of Anesthesiology and Critical Care, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
  • Maddux AB; Division of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN, 46202, USA.
  • Shein SL; Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
  • Crandall H; Division of Pediatric Critical Care Medicine, Department of Pediatrics, Mott Children's Hospital and University of Michigan, Ann Arbor, MI, 48109, USA.
  • Hume JR; Department of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, 80045, USA.
  • Hobbs CV; Division of Pediatric Critical Care Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH, 44106, USA.
  • Tremoulet AH; Division of Pediatric Critical Care, Department of Pediatrics, University of Utah, Salt Lake City, UT, 84113, USA.
  • Shimizu C; Division of Pediatric Critical Care, University of Minnesota Masonic Children's Hospital, Minneapolis, MN, 55454, USA.
  • Burns JC; Department of Pediatrics, Department of Microbiology, Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS, 39202, USA.
  • Chen SR; Kawasaki Disease Research Center, Rady Children's Hospital and Department of Pediatrics, UCSD School of Medicine, La Jolla, CA, 92093, USA.
  • Moon HK; Kawasaki Disease Research Center, Rady Children's Hospital and Department of Pediatrics, UCSD School of Medicine, La Jolla, CA, 92093, USA.
  • Lange C; Kawasaki Disease Research Center, Rady Children's Hospital and Department of Pediatrics, UCSD School of Medicine, La Jolla, CA, 92093, USA.
  • Randolph AG; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
  • Khurana S; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Nat Commun ; 13(1): 2979, 2022 05 27.
Article in English | MEDLINE | ID: covidwho-1931398
ABSTRACT
Neutralization capacity of antibodies against Omicron after a prior SARS-CoV-2 infection in children and adolescents is not well studied. Therefore, we evaluated virus-neutralizing capacity against SARS-CoV-2 Alpha, Beta, Gamma, Delta and Omicron variants by age-stratified analyses (<5, 5-11, 12-21 years) in 177 pediatric patients hospitalized with severe acute COVID-19, acute MIS-C, and in convalescent samples of outpatients with mild COVID-19 during 2020 and early 2021. Across all patients, less than 10% show neutralizing antibody titers against Omicron. Children <5 years of age hospitalized with severe acute COVID-19 have lower neutralizing antibodies to SARS-CoV-2 variants compared with patients >5 years of age. As expected, convalescent pediatric COVID-19 and MIS-C cohorts demonstrate higher neutralization titers than hospitalized acute COVID-19 patients. Overall, children and adolescents show some loss of cross-neutralization against all variants, with the most pronounced loss against Omicron. In contrast to SARS-CoV-2 infection, children vaccinated twice demonstrated higher titers against Alpha, Beta, Gamma, Delta and Omicron. These findings can influence transmission, re-infection and the clinical disease outcome from emerging SARS-CoV-2 variants and supports the need for vaccination in children.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines / Variants Limits: Adolescent / Child / Child, preschool / Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-30649-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines / Variants Limits: Adolescent / Child / Child, preschool / Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-30649-1