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SARS-CoV-2 RNA in exhaled air of hospitalized COVID-19 patients.
Kurver, Lisa; van den Kieboom, Corné H; Lanke, Kjerstin; Diavatopoulos, Dimitri A; Overheul, Gijs J; Netea, Mihai G; Ten Oever, Jaap; van Crevel, Reinout; Mulders-Manders, Karin; van de Veerdonk, Frank L; Wertheim, Heiman; Schouten, Jeroen; Rahamat-Langendoen, Janette; van Rij, Ronald P; Bousema, Teun; van Laarhoven, Arjan; de Jonge, Marien I.
  • Kurver L; Department of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
  • van den Kieboom CH; Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, route 469, Nijmegen, 6525 GA, The Netherlands.
  • Lanke K; Xheal Diagnostics B.V, 6525 GC, Nijmegen, The Netherlands.
  • Diavatopoulos DA; Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
  • Overheul GJ; Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, route 469, Nijmegen, 6525 GA, The Netherlands.
  • Netea MG; Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
  • Ten Oever J; Department of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
  • van Crevel R; Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, 53115, Bonn, Germany.
  • Mulders-Manders K; Department of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
  • van de Veerdonk FL; Department of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
  • Wertheim H; Department of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
  • Schouten J; Department of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
  • Rahamat-Langendoen J; Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
  • van Rij RP; Department of Intensive Care Medicine, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
  • Bousema T; Department of Medical Microbiology, Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
  • van Laarhoven A; Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
  • de Jonge MI; Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Sci Rep ; 12(1): 8991, 2022 05 30.
Article in English | MEDLINE | ID: covidwho-1947470
ABSTRACT
Knowledge about contagiousness is key to accurate management of hospitalized COVID-19 patients. Epidemiological studies suggest that in addition to transmission through droplets, aerogenic SARS-CoV-2 transmission contributes to the spread of infection. However, the presence of virus in exhaled air has not yet been sufficiently demonstrated. In pandemic situations low tech disposable and user-friendly bedside devices are required, while commercially available samplers are unsuitable for application in patients with respiratory distress. We included 49 hospitalized COVID-19 patients and used a disposable modular breath sampler to measure SARS-CoV-2 RNA load in exhaled air samples and compared these to SARS-CoV-2 RNA load of combined nasopharyngeal throat swabs and saliva. Exhaled air sampling using the modular breath sampler has proven feasible in a clinical COVID-19 setting and demonstrated viral detection in 25% of the patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-13008-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-13008-4