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Social Vulnerability and Rurality Associated With Higher Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection-Induced Seroprevalence: A Nationwide Blood Donor Study-United States, July 2020-June 2021.
Li, Zheng; Lewis, Brian; Berney, Kevin; Hallisey, Elaine; Williams, Austin M; Whiteman, Ari; Rivera-González, Luis O; Clarke, Kristie E N; Clayton, Heather B; Tincher, Terry; Opsomer, Jean D; Busch, Michael P; Gundlapalli, Adi V; Jones, Jefferson M.
  • Li Z; COVID-19 Response, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
  • Lewis B; Geospatial Research, Analysis, and Services Program (GRASP), Agency for Toxic Substances and Disease Registry, CDC, Atlanta, Georgia, USA.
  • Berney K; Geospatial Research, Analysis, and Services Program (GRASP), Agency for Toxic Substances and Disease Registry, CDC, Atlanta, Georgia, USA.
  • Hallisey E; Geospatial Research, Analysis, and Services Program (GRASP), Agency for Toxic Substances and Disease Registry, CDC, Atlanta, Georgia, USA.
  • Williams AM; COVID-19 Response, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
  • Whiteman A; Geospatial Research, Analysis, and Services Program (GRASP), Agency for Toxic Substances and Disease Registry, CDC, Atlanta, Georgia, USA.
  • Rivera-González LO; COVID-19 Response, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
  • Clarke KEN; COVID-19 Response, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
  • Clayton HB; COVID-19 Response, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
  • Tincher T; COVID-19 Response, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
  • Opsomer JD; WESTAT, Inc, Rockville, Maryland, USA.
  • Busch MP; Vitalant Research Institute, San Francisco, California, USA.
  • Gundlapalli AV; COVID-19 Response, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
  • Jones JM; COVID-19 Response, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
Clin Infect Dis ; 75(1): e133-e143, 2022 08 24.
Article in English | MEDLINE | ID: covidwho-1868253
ABSTRACT

BACKGROUND:

Most studies on health disparities during the coronavirus disease 2019 (COVID-19) pandemic focused on reported cases and deaths, which are influenced by testing availability and access to care. This study aimed to examine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody seroprevalence in the United States and its associations with race/ethnicity, rurality, and social vulnerability over time.

METHODS:

This repeated cross-sectional study used data from blood donations in 50 states and Washington, DC, from July 2020 through June 2021. Donor zip codes were matched to counties and linked with Social Vulnerability Index (SVI) and urban-rural classification. SARS-CoV-2 antibody seroprevalences induced by infection and infection-vaccination combined were estimated. Association of infection-induced seropositivity with demographics, rurality, SVI, and its 4 themes were quantified using multivariate regression models.

RESULTS:

Weighted seroprevalence differed significantly by race/ethnicity and rurality, and increased with increasing social vulnerability. During the study period, infection-induced seroprevalence increased from 1.6% to 27.2% and 3.7% to 20.0% in rural and urban counties, respectively, while rural counties had lower combined infection- and vaccination-induced seroprevalence (80.0% vs 88.1%) in June 2021. Infection-induced seropositivity was associated with being Hispanic, non-Hispanic Black, and living in rural or more socially vulnerable counties, after adjusting for demographic and geographic covariates.

CONCLUSIONS:

The findings demonstrated increasing SARS-CoV-2 seroprevalence in the United States across all geographic, demographic, and social sectors. The study illustrated disparities by race-ethnicity, rurality, and social vulnerability. The findings identified areas for targeted vaccination strategies and can inform efforts to reduce inequities and prepare for future outbreaks.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Infections Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Infections Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid