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Post-vaccination analysis of anti-spike antibody responses in kidney transplant recipients with and without COVID-19 infection in a tertiary care centre, India.
Jasuja, Sanjiv; Jha, Vivekanand; Sagar, Gaurav; Bahl, Anupam; Verma, Shalini; Jasuja, Neharita; Kaur, Jasmeet.
  • Jasuja S; Department of Nephrology, Indraprastha Apollo Hospital, New Delhi, India.
  • Jha V; George Institute for Global Health, UNSW, New Delhi, India.
  • Sagar G; Department of Nephrology, Indraprastha Apollo Hospital, New Delhi, India.
  • Bahl A; Department of Nephrology, Indraprastha Apollo Hospital, New Delhi, India.
  • Verma S; Department of Clinical Research, AVATAR Foundation, New Delhi, India.
  • Jasuja N; Department of Clinical Research, AVATAR Foundation, New Delhi, India.
  • Kaur J; Department of Histocompatibility and Transplant Immunology, Dr Lal PathLabs Ltd, National Reference Laboratory, New Delhi, India.
Clin Kidney J ; 15(7): 1312-1321, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1868268
ABSTRACT

Background:

To investigate the anti-spike antibody response to vaccination in kidney transplant recipients (KTRs) previously infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as compared with KTRs with no history of coronavirus disease 2019 (COVID-19) from India.

Methods:

SARS-CoV-2 spike immunoglobulin (Ig) G antibody response was measured in 105 post-COVID-19 KTRs with PCR-confirmed SARS-CoV-2 infection who received either no vaccination (cohort 1), a single dose (cohort 2) or two doses (cohort 3) of vaccine and compared with 103 two-dose vaccinated COVID-19-naïve KTRs with no history of COVID-19 (cohort 4).

Results:

Out of 103 COVID-19-naïve two-dose vaccinated KTRs, <50% became seropositive with anti-spike antibody titres >50 arbitrary unit/mL subsequent to complete vaccination, the seroconversion rate being comparable in subjects receiving CovishieldTM versus CovaxinTM vaccines. However, the seropositive KTRs vaccinated with CovishieldTM had higher anti-spike antibody titres as compared with those who received CovaxinTM. We observed higher anti-SARS-CoV-2 spike antibody levels in post-COVID-19 KTRs after one dose of vaccine as compared with COVID-19-naïve two-dose vaccinated KTRs. Importantly, the second dose in post-COVID-19 KTRs did not significantly increase anti-spike antibody levels compared with the single-dose recipients.

Conclusions:

Our data present that in KTRs with previous SARS-CoV-2 infection, a single dose of vaccine (CovishieldTM) may be effective in mounting an optimal immune response. In contrast, COVID-19-naïve two-dose vaccinated KTRs respond poorly (<50%) to the current recommendation of a two-dose regimen in India.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid / Vaccines Language: English Journal: Clin Kidney J Year: 2022 Document Type: Article Affiliation country: Ckj

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid / Vaccines Language: English Journal: Clin Kidney J Year: 2022 Document Type: Article Affiliation country: Ckj