Your browser doesn't support javascript.
RAGE has potential pathogenetic and prognostic value in nonintubated hospitalized patients with COVID-19.
Wick, Katherine D; Siegel, Lianne; Neaton, James D; Oldmixon, Cathryn; Lundgren, Jens; Dewar, Robin L; Lane, H Clifford; Thompson, B Taylor; Matthay, Michael A.
  • Wick KD; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
  • Siegel L; Division of Biostatistics and.
  • Neaton JD; Division of Biostatistics and.
  • Oldmixon C; Division of Infectious Diseases, University of Minnesota, Minneapolis, Minnesota, USA.
  • Lundgren J; Division of Biostatistics, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Dewar RL; Centre of Excellence for Health, Immunity and Infections, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Lane HC; Virus Isolation and Serology Laboratory, Applied and Developmental Research Directorate, Frederick National Laboratory, Frederick, Maryland, USA.
  • Thompson BT; Division of Clinical Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
  • Matthay MA; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Maryland, USA.
JCI Insight ; 7(9)2022 05 09.
Article in English | MEDLINE | ID: covidwho-1868830
ABSTRACT
BackgroundThe value of the soluble receptor for advanced glycation end-products (sRAGE) as a biomarker in COVID-19 is not well understood. We tested the association between plasma sRAGE and illness severity, viral burden, and clinical outcomes in hospitalized patients with COVID-19 who were not mechanically ventilated.MethodsBaseline sRAGE was measured among participants enrolled in the ACTIV-3/TICO trial of bamlanivimab for hospitalized patients with COVID-19. Spearman's rank correlation was used to assess the relationship between sRAGE and other plasma biomarkers, including viral nucleocapsid antigen. Fine-Gray models adjusted for baseline supplemental oxygen requirement, antigen level, positive endogenous anti-nucleocapsid antibody response, sex, age, BMI, diabetes mellitus, renal impairment, corticosteroid treatment, and log2-transformed IL-6 level were used to assess the association between baseline sRAGE and time to sustained recovery. Cox regression adjusted for the same factors was used to assess the association between sRAGE and mortality.ResultsAmong 277 participants, baseline sRAGE was strongly correlated with viral plasma antigen concentration (ρ = 0.57). There was a weaker correlation between sRAGE and biomarkers of systemic inflammation, such as IL-6 (ρ = 0.36) and CRP (ρ = 0.20). Participants with plasma sRAGE in the highest quartile had a significantly lower rate of sustained recovery (adjusted recovery rate ratio, 0.64 [95% CI, 0.43-0.90]) and a higher unadjusted risk of death (HR, 4.70 [95% CI, 2.01-10.99]) compared with participants in the lower quartiles.ConclusionElevated plasma sRAGE in hospitalized, nonventilated patients with COVID-19 was an indicator of both clinical illness severity and plasma viral load. Plasma sRAGE in the highest quartile was associated with a lower likelihood of sustained recovery and higher unadjusted risk of death. These findings, which we believe to be novel, indicate that plasma sRAGE may be a promising biomarker for COVID-19 prognostication and clinical trial enrichment.Trial RegistrationClinicalTrials.gov NCT04501978.FundingNIH (5T32GM008440-24, 18X107CF6, HHSN261201500003I, R35HL140026, and OT2HL156812).
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study / Randomized controlled trials Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Jci.insight.157499

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study / Randomized controlled trials Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Jci.insight.157499