Hematological features and risk factors of hospitalized COVID-19 patients: A retrospective analysis
European Journal of Inflammation
; 17, 2022.
Article
in English
| EMBASE | ID: covidwho-1868842
ABSTRACT
Background:
Coronavirus disease 2019 (COVID-19) became pandemic in 2020 and recently, mutated coronaviruses have emerged in many countries. The aim of this study was to identify the clinical characteristics and risk factors for critical illness in hospitalized COVID-19 patients in Zhengzhou for clinical prevention and management. Materials andmethods:
A total of 70 patients hospitalized with COVID-19 were enrolled between 21 January and 29 February 2020, in Zhengzhou, China. Clinical characteristics, hematological findings, neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and inflammatory index on admission were obtained from medical records, COVID-19 patients with different outcomes were compared.Results:
The median age was 55 years. Forty-three (61.0%) patients were classified as having severe or critical cases. Eighteen (25.7%) patients died in hospital and the remaining 52 were discharged. Patients who died tend to be old with expectoration and chronic obstructive pulmonary disease. Compared to survivor, non-survivor had significantly higher numbers of leucocytes and neutrophils, NLR, aspartate aminotransferase (AST), γ-glutamyl transpeptidase, total bilirubin, direct bilirubin, lactate dehydrogenase (LDH), prothrombin time, D-dimer, C-reactive protein, and decreased platelets, lymphocytes, uric acid, and albumin (ALB). Logistic regression analysis identified leucocytes, platelets, PLR, NLR, AST, and ALB as independent predictive factors for poor outcomes. The area under curve of the combination of leucocytes, PLR, NLR, and AST was 0.87, with a sensitivity of 0.83 and specificity of 0.81.Conclusion:
Our results identified risk factors among COVID-19 patients for in-hospital mortality. Leucocytes, PLR, NLR, and AST could have important reference value for predicting prognosis, especially in low-resource countries.
adult; area under the curve; article; China; chronic obstructive lung disease; clinical feature; controlled study; coronavirus disease 2019; critical illness; female; hospital mortality; human; human cell; in-hospital mortality; leukocyte; lymphocyte; major clinical study; male; medical record; middle aged; neutrophil; neutrophil lymphocyte ratio; nonhuman; outcome assessment; platelet lymphocyte ratio; prevention; prognosis; prothrombin time; reference value; retrospective study; risk assessment; risk factor; sensitivity and specificity; Severe acute respiratory syndrome coronavirus 2; sputum; survivor; albumin; aspartate aminotransferase; bilirubin; bilirubin glucuronide; C reactive protein; D dimer; endogenous compound; gamma glutamyltransferase; lactate dehydrogenase; uric acid
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
European Journal of Inflammation
Year:
2022
Document Type:
Article
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