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SARS-CoV-2 seroprevalence among healthcare workers.
Wiggen, Talia D; Bohn, Bruno; Ulrich, Angela K; Stovitz, Steven D; Strickland, Ali J; Naumchik, Brianna M; Walsh, Sara; Smith, Stephen; Baumgartner, Brett; Kline, Susan; Yendell, Stephanie; Hedberg, Craig; Beebe, Timothy J; Demmer, Ryan T.
  • Wiggen TD; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, United States of America.
  • Bohn B; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, United States of America.
  • Ulrich AK; Center for Infectious Disease Research and Policy, University of Minnesota, Minneapolis, MN, United States of America.
  • Stovitz SD; Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, MN, United States of America.
  • Strickland AJ; Department of Family Medicine and Community Health, Medical School, University of Minnesota, Minneapolis, MN, United States of America.
  • Naumchik BM; Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, MN, United States of America.
  • Walsh S; Medical School, University of Minnesota, Minneapolis, MN, United States of America.
  • Smith S; NORC at the University of Chicago, Health Sciences, Chicago, IL, United States of America.
  • Baumgartner B; NORC at the University of Chicago, Health Sciences, Chicago, IL, United States of America.
  • Kline S; Quansys Biosciences, Logan, UT, United States of America.
  • Yendell S; Division of Infectious Diseases and International Medicine, Medical School, University of Minnesota, Minneapolis, MN, United States of America.
  • Hedberg C; Minnesota Department of Health, St. Paul, MN, United States of America.
  • Beebe TJ; Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, MN, United States of America.
  • Demmer RT; Division of Health Policy and Management, School of Public Health, University of Minnesota, Minneapolis, MN, United States of America.
PLoS One ; 17(4): e0266410, 2022.
Article in English | MEDLINE | ID: covidwho-2089338
ABSTRACT

BACKGROUND:

Monitoring COVID-19 infection risk among health care workers (HCWs) is a public health priority. We examined the seroprevalence of SARS-CoV-2 among HCWs following the fall infection surge in Minnesota, and before and after COVID-19 vaccination. Additionally, we assessed demographic and occupational risk factors for SARS-CoV-2 infection.

METHODS:

We conducted two rounds of seroprevalence testing among a cohort of HCWs samples in round 1 were collected from 11/22/20-02/21/21 and in round 2 from 12/18/20-02/15/21. Demographic and occupational exposures assessed with logistic regression were age, sex, healthcare role and setting, and number of children in the household. The primary outcome was SARS-CoV-2 IgG seropositivity. A secondary outcome, SARS-CoV-2 infection, included both seropositivity and self-reported SARS-CoV-2 test positivity.

RESULTS:

In total, 459 HCWs were tested. 43/454 (9.47%) had a seropositive sample 1 and 75/423 (17.7%) had a seropositive sample 2. By time of sample 2 collection, 54% of participants had received at least one vaccine dose and seroprevalence was 13% among unvaccinated individuals. Relative to physicians, the odds of SARS-CoV-2 infection in other roles were increased (Nurse Practitioner OR[95%CI] 1.93[0.57,6.53], Physician's Assistant 1.69[0.38,7.52], Nurse 2.33[0.94,5.78], Paramedic/EMTs 3.86[0.78,19.0], other 1.68[0.58,4.85]). The workplace setting was associated with SARS-CoV-2 infection (p = 0.04). SARS-CoV-2 seroprevalence among HCWs reporting duties in the ICU vs. those working in an ambulatory clinic was elevated OR[95%CI] 2.17[1.01,4.68].

CONCLUSIONS:

SARS-CoV-2 seroprevalence in HCW increased during our study period which was consistent with community infection rates. HCW role and setting-particularly working in the ICU-is associated with higher risk for SARS-CoV-2 infection.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Child / Humans Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0266410

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Child / Humans Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0266410