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Frequency of exposure to arboviruses and characterization of Guillain Barré syndrome in a clinical cohort of patients treated at a tertiary referral center in Brasília, Federal District.
Matos, Luíza Morais de; Borges, Ariely Teotonio; Palmeira, Aline Barbosa; Lima, Vinicius Moreira; Maciel, Ernane Pires; Fernandez, Rubens Nelson Morato; Mendes, João Pedro Lima; Romero, Gustavo Adolfo Sierra.
  • Matos LM; Universidade de Brasília, Faculdade de Medicina, Núcleo de Medicina Tropical, Brasília, DF, Brasil.
  • Borges AT; Instituto Hospital de Base do Distrito Federal, Unidade de Infectologia, Brasília, DF, Brasil.
  • Palmeira AB; Instituto Hospital de Base do Distrito Federal, Unidade de Neurologia, Brasília, DF, Brasil.
  • Lima VM; Instituto Hospital de Base do Distrito Federal, Unidade de Neurologia, Brasília, DF, Brasil.
  • Maciel EP; Instituto Hospital de Base do Distrito Federal, Unidade de Neurologia, Brasília, DF, Brasil.
  • Fernandez RNM; Instituto Hospital de Base do Distrito Federal, Unidade de Neurologia, Brasília, DF, Brasil.
  • Mendes JPL; Instituto Hospital de Base do Distrito Federal, Unidade de Neurologia, Brasília, DF, Brasil.
  • Romero GAS; Universidade de Brasília, Faculdade de Medicina, Núcleo de Medicina Tropical, Brasília, DF, Brasil.
Rev Soc Bras Med Trop ; 55: e03062021, 2022.
Article in English | MEDLINE | ID: covidwho-1869217
ABSTRACT

BACKGROUND:

Guillian Barré syndrome (GBS) is an acute autoimmune polyradiculoneuropathy often associated with previous exposure to infectious agents.

METHODS:

A clinical cohort of 41 patients with GBS admitted to the Base Hospital Institute of the Federal District between May 2017 and April 2019 was followed up for 1 year. Serological tests for arbovirus detection and amplification of nucleic acids using polymerase chain reaction for zika virus (ZIKV), dengue virus (DENV), and chikungunya virus (CHIKV) were performed.

RESULTS:

The cohort consisted of 61% men with a median age of 40 years, and 83% had GBS-triggering events. A total of 54% had Grade 4 disability, 17% had Grade 3, 12% had Grade 2, 10% had Grade 5, and 7% had Grade 1. The classic form occurred in 83% of patients. Nerve conduction evaluations revealed acute demyelinating inflammatory polyneuropathy (51%), acute motor axonal neuropathy (17%), acute sensory-motor neuropathy (15%), and indeterminate forms (17%). Four patients were seropositive for DENV. There was no laboratory detection of ZIKV or CHIKV infection. Ninety percent of patients received human immunoglobulin. Intensive care unit admission occurred in 17.1% of the patients, and mechanical ventilation was used in 14.6%. One patient died of Bickerstaff's encephalitis. Most patients showed an improvement in disability at 10 weeks of follow-up.

CONCLUSIONS:

GBS in the Federal District showed a variable clinical spectrum, and it was possible to detect recent exposure to DENV.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Arboviruses / Guillain-Barre Syndrome / Zika Virus / Zika Virus Infection Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Rev Soc Bras Med Trop Year: 2022 Document Type: Article Affiliation country: 0037-8682-0306-2021

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arboviruses / Guillain-Barre Syndrome / Zika Virus / Zika Virus Infection Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Rev Soc Bras Med Trop Year: 2022 Document Type: Article Affiliation country: 0037-8682-0306-2021