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Transmission dynamics of COVID-19 in household and community settings in the United Kingdom, January to March 2020.
Lopez Bernal, Jamie; Panagiotopoulos, Nikolaos; Byers, Chloe; Garcia Vilaplana, Tatiana; Boddington, Nicki; Zhang, Xu-Sheng; Charlett, Andre; Elgohari, Suzanne; Coughlan, Laura; Whillock, Rosie; Logan, Sophie; Bolt, Hikaru; Sinnathamby, Mary; Letley, Louise; MacDonald, Pauline; Vivancos, Roberto; Edeghere, Obaghe; Anderson, Charlotte; Paranthaman, Karthik; Cottrell, Simon; McMenamin, Jim; Zambon, Maria; Dabrera, Gavin; Ramsay, Mary; Saliba, Vanessa.
  • Lopez Bernal J; Immunisation and Countermeasures Department, Public Health England, London, United Kingdom.
  • Panagiotopoulos N; Statistics, Modelling and Economics Department, Public Health England, London, United Kingdom.
  • Byers C; Immunisation and Countermeasures Department, Public Health England, London, United Kingdom.
  • Garcia Vilaplana T; Immunisation and Countermeasures Department, Public Health England, London, United Kingdom.
  • Boddington N; Immunisation and Countermeasures Department, Public Health England, London, United Kingdom.
  • Zhang XS; Statistics, Modelling and Economics Department, Public Health England, London, United Kingdom.
  • Charlett A; Statistics, Modelling and Economics Department, Public Health England, London, United Kingdom.
  • Elgohari S; Immunisation and Countermeasures Department, Public Health England, London, United Kingdom.
  • Coughlan L; Immunisation and Countermeasures Department, Public Health England, London, United Kingdom.
  • Whillock R; Immunisation and Countermeasures Department, Public Health England, London, United Kingdom.
  • Logan S; Field Services Division, Public Health England, London, United Kingdom.
  • Bolt H; Field Services Division, Public Health England, London, United Kingdom.
  • Sinnathamby M; Immunisation and Countermeasures Department, Public Health England, London, United Kingdom.
  • Letley L; Immunisation and Countermeasures Department, Public Health England, London, United Kingdom.
  • MacDonald P; Immunisation and Countermeasures Department, Public Health England, London, United Kingdom.
  • Vivancos R; Field Services Division, Public Health England, London, United Kingdom.
  • Edeghere O; Field Services Division, Public Health England, London, United Kingdom.
  • Anderson C; Field Services Division, Public Health England, London, United Kingdom.
  • Paranthaman K; Field Services Division, Public Health England, London, United Kingdom.
  • Cottrell S; Public Health Wales, Cardiff, United Kingdom.
  • McMenamin J; Health Protection Scotland, Glasgow, United Kingdom.
  • Zambon M; TARGET Department, Public Health England, London, United Kingdom.
  • Dabrera G; TARGET Department, Public Health England, London, United Kingdom.
  • Ramsay M; Immunisation and Countermeasures Department, Public Health England, London, United Kingdom.
  • Saliba V; Immunisation and Countermeasures Department, Public Health England, London, United Kingdom.
Euro Surveill ; 27(15)2022 04.
Article in English | MEDLINE | ID: covidwho-1869325
ABSTRACT
BackgroundHouseholds appear to be the highest risk setting for COVID-19 transmission. Large household transmission studies in the early stages of the pandemic in Asia reported secondary attack rates ranging from 5 to 30%.AimWe aimed to investigate the transmission dynamics of COVID-19 in household and community settings in the UK.MethodsA prospective case-ascertained study design based on the World Health Organization FFX protocol was undertaken in the UK following the detection of the first case in late January 2020. Household contacts of cases were followed using enhanced surveillance forms to establish whether they developed symptoms of COVID-19, became confirmed cases and their outcomes. We estimated household secondary attack rates (SAR), serial intervals and individual and household basic reproduction numbers. The incubation period was estimated using known point source exposures that resulted in secondary cases.ResultsWe included 233 households with two or more people with 472 contacts. The overall household SAR was 37% (95% CI 31-43%) with a mean serial interval of 4.67 days, an R0 of 1.85 and a household reproduction number of 2.33. SAR were lower in larger households and highest when the primary case was younger than 18 years. We estimated a mean incubation period of around 4.5 days.ConclusionsRates of COVID-19 household transmission were high in the UK for ages above and under 18 years, emphasising the need for preventative measures in this setting. This study highlights the importance of the FFX protocol in providing early insights on transmission dynamics.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Topics: Long Covid Limits: Adolescent / Humans Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: 1560-7917.Es.2022.27.15.2001551

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Topics: Long Covid Limits: Adolescent / Humans Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: 1560-7917.Es.2022.27.15.2001551