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Antibiotic Prescription and In-Hospital Mortality in COVID-19: A Prospective Multicentre Cohort Study.
Pinte, Larisa; Ceasovschih, Alexandr; Niculae, Cristian-Mihail; Stoichitoiu, Laura Elena; Ionescu, Razvan Adrian; Balea, Marius Ioan; Cernat, Roxana Carmen; Vlad, Nicoleta; Padureanu, Vlad; Purcarea, Adrian; Badea, Camelia; Hristea, Adriana; Sorodoc, Laurentiu; Baicus, Cristian.
  • Pinte L; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Ceasovschih A; Department of Internal Medicine, Colentina Clinical Hospital, 020125 Bucharest, Romania.
  • Niculae CM; Clinical Research Unit, Reseau d'Epidemiologie Clinique International Francophone, 020125 Bucharest, Romania.
  • Stoichitoiu LE; Department of Internal Medicine, Clinical Emergency Hospital Sfantul Spiridon, 700111 Iasi, Romania.
  • Ionescu RA; Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
  • Balea MI; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Cernat RC; Department of Infectious Diseases, National Institute for Infectious Diseases Prof. Dr. Matei Bals, 021105 Bucharest, Romania.
  • Vlad N; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Padureanu V; Department of Internal Medicine, Colentina Clinical Hospital, 020125 Bucharest, Romania.
  • Purcarea A; Clinical Research Unit, Reseau d'Epidemiologie Clinique International Francophone, 020125 Bucharest, Romania.
  • Badea C; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Hristea A; Department of Internal Medicine, Colentina Clinical Hospital, 020125 Bucharest, Romania.
  • Sorodoc L; Clinical Research Unit, Reseau d'Epidemiologie Clinique International Francophone, 020125 Bucharest, Romania.
  • Baicus C; Department of Pneumology, Colentina Clinical Hospital, 020125 Bucharest, Romania.
J Pers Med ; 12(6)2022 May 26.
Article in English | MEDLINE | ID: covidwho-1869681
ABSTRACT

BACKGROUND:

Since the beginning of the COVID-19 pandemic, empiric antibiotics (ATBs) have been prescribed on a large scale in both in- and outpatients. We aimed to assess the impact of antibiotic treatment on the outcomes of hospitalised patients with moderate and severe coronavirus disease 2019 (COVID-19).

METHODS:

We conducted a prospective multicentre cohort study in six clinical hospitals, between January 2021 and May 2021.

RESULTS:

We included 553 hospitalised COVID-19 patients, of whom 58% (311/553) were prescribed antibiotics, while bacteriological tests were performed in 57% (178/311) of them. Death was the outcome in 48 patients-39 from the ATBs group and 9 from the non-ATBs group. The patients who received antibiotics during hospitalisation had a higher mortality (RR = 3.37, CI 95% 1.7-6.8), and this association was stronger in the subgroup of patients without reasons for antimicrobial treatment (RR = 6.1, CI 95% 1.9-19.1), while in the subgroup with reasons for antimicrobial therapy the association was not statistically significant (OR = 2.33, CI 95% 0.76-7.17). After adjusting for the confounders, receiving antibiotics remained associated with a higher mortality only in the subgroup of patients without criteria for antibiotic prescription (OR = 10.3, CI 95% 2-52).

CONCLUSIONS:

In our study, antibiotic treatment did not decrease the risk of death in the patients with mild and severe COVID-19, but was associated with a higher risk of death in the subgroup of patients without reasons for it.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Jpm12060877

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Jpm12060877