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Gastrointestinal Involvement in SARS-CoV-2 Infection.
Chen, Tsung-Hsien; Hsu, Ming-Tse; Lee, Ming-Yang; Chou, Chu-Kuang.
  • Chen TH; Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 60002, Taiwan.
  • Hsu MT; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 60002, Taiwan.
  • Lee MY; Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 60002, Taiwan.
  • Chou CK; Division of Hemato-Oncology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 60002, Taiwan.
Viruses ; 14(6)2022 05 30.
Article in English | MEDLINE | ID: covidwho-1869827
ABSTRACT
SARS-CoV-2 has evolved into a virus that primarily results in mild or asymptomatic disease, making its transmission more challenging to control. In addition to the respiratory tract, SARS-CoV-2 also infects the digestive tract. Some gastrointestinal symptoms occur with or before respiratory symptoms in patients with COVID-19. Respiratory infections are known to cause intestinal immune impairment and gastrointestinal symptoms. When the intestine is inflamed, cytokines affect the lung immune response and inflammation through blood circulation. The gastrointestinal microbiome may be a modifiable factor in determining the risk of SARS-CoV-2 infection and disease severity. The development of oral SARS-CoV-2 vaccine candidates and the maintenance of gut microbiota profiles may contribute to the early control of COVID-19 outbreaks. To this end, this review summarizes information on the gastrointestinal complications caused by SARS-CoV-2, SARS-CoV-2 infection, the gastrointestinal-lung axis immune response, potential control strategies for oral vaccine candidates and maintaining intestinal microbiota homeostasis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Microbiome / Gastrointestinal Diseases / COVID-19 Type of study: Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14061188

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Microbiome / Gastrointestinal Diseases / COVID-19 Type of study: Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14061188