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A Paradigm Shift in the Combination Changes of SARS-CoV-2 Variants and Increased Spread of Delta Variant (B.1.617.2) across the World.
Chakraborty, Chiranjib; Sharma, Ashish Ranjan; Bhattacharya, Manojit; Agoramoorthy, Govindasamy; Lee, Sang-Soo.
  • Chakraborty C; 1Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Kolkata, West Bengal 700126, India.
  • Sharma AR; 2Institute for Skeletal Aging & Orthopaedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Gangwon-do, Korea.
  • Bhattacharya M; 3Department of Zoology, Fakir Mohan University, Vyasa Vihar, Odisha, India.
  • Agoramoorthy G; 4College of Pharmacy and Health Care, Tajen University, Pingtung, Taiwan.
  • Lee SS; 2Institute for Skeletal Aging & Orthopaedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Gangwon-do, Korea.
Aging Dis ; 13(3): 927-942, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1870133
ABSTRACT
Since September 2020, the SARS-CoV-2 variants have gained their dominance worldwide, especially in Kenya, Italy, France, the UK, Turkey, Indonesia, India, Finland, Ireland, Singapore, Denmark, Germany, and Portugal. In this study, we developed a model on the frequency of delta variants across 28 countries (R2= 0.1497), displaying the inheritance of mutations during the generation of the delta variants with 123,526 haplotypes. The country-wise haplotype network showed the distribution of haplotypes in USA (10,174), Denmark (5,637), India (4,089), Germany (2,350), Netherlands (1,899), Sweden (1,791), Italy (1,720), France (1,293), Ireland (1,257), Belgium (1,207), Singapore (1,193), Portugal (1,184) and Spain (1,133). Our analysis shows the highest haplotype in Europe with 84% and the lowest in Australia with 0.00001%. A model of scatter plot was generated with a regression line which provided the estimated rate of mutation, including 24.048 substitutions yearly. Our study concluded that the high global prevalence of the delta variants is due to a high frequency of infectivity, supporting the paradigm shift of the viral variants.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Topics: Variants Language: English Journal: Aging Dis Year: 2022 Document Type: Article Affiliation country: AD.2021.1117

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Topics: Variants Language: English Journal: Aging Dis Year: 2022 Document Type: Article Affiliation country: AD.2021.1117