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Antioxidant activity of Curcumin
Research Journal of Pharmacy and Technology ; 14(12):6741-6746, 2021.
Article in English | ProQuest Central | ID: covidwho-1870536
ABSTRACT
Curcumin (Figure 1) with two ferulic acid moieties bonded with carbon of a methane molecule to create an abridgement between the carboxyl groups, with a molecular weight of 368.37 g/mol and melting point of 183° C. Curcumin consists of 3 core functional groups consisting of O-methoxy-phenolic group and a, ßunsaturated system of ß-diketone moiety which is including of 7-carbon linker. Many researches (table1) have been approved that curcumin can scavenge hydrogen peroxide, superoxide anion radical and nitric oxide that formed by macrophages, thus antioxidant activity of curcumin is believed to happen through increase the degradation of haemoglobin and by inhibiting the lipid peroxidation process46. [...]curcumin also constrains the nitric oxide synthase action of macrophages as well. Therapeutically, it could be beneficial in the treatment of diabetic retinopathy, by studied the damage effect of high glucose intake in retinal pigment epithelial cell, it found that, curcumin protect these cells through the activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) expression and HO-153 Curcumin can also bind with metal ion to form metal complex that shows significant benefit in term of antioxidant when comparing with curcumin alone 54.
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Collection: Databases of international organizations Database: ProQuest Central Language: English Journal: Research Journal of Pharmacy and Technology Year: 2021 Document Type: Article

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Collection: Databases of international organizations Database: ProQuest Central Language: English Journal: Research Journal of Pharmacy and Technology Year: 2021 Document Type: Article