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Philippine medicinal plants with potentialimmunomodulatory and anti-SARS-CoV-2 activities
Philippine Journal of Science ; 150(5):999-1015, 2021.
Article in English | CAB Abstracts | ID: covidwho-1870814
ABSTRACT
Coronavirus disease 2019 (COVID-19) continues to devastate the world's health and economy, affecting all aspects of life leading to widespread social disruption. Even as several vaccines have been developed, their availability in developing countries is limited and their efficacy against the variants of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus 2) needs to be continuously assessed. The World Health Organization (WHO) has acknowledged that vaccines alone will not overcome the global challenges of COVID-19. Medicinal plants may provide the needed support. Herein, we identify Philippine medicinal plants that possess phytochemicals with potential anti-SARS-CoV-2 activity and/or immunomodulatory properties that may strengthen one's immune system against COVID-19. These plants were selected from 100 of the best-studied Philippine medicinal plants with antiviral and immunomodulatory properties. The general antiviral and specific anti-SARS-CoV-2 activities and immunomodulatory properties of the phytochemicals that these plants contained were searched. While many compounds assessed individually using in vitro and in silico techniques suggest potential anti-SARS-CoV-2 or immunomodulatory effects, this review sought to identify the medicinal plants which contain these compounds and which, based on literature, have the best potential application against COVID-19. These plants are Allium spp. bulbs (bawang), Andrographis paniculata (Burm.f.) Nees leaves (sinta), Cocos nucifera L. oil (niyog), Euphorbia hirta L. leaves (tawa-tawa), Euphorbia neriifolia L. leaves (sorosoro), Moringa oleifera Lam. leaves (malunggay), Ocimum basilicum L. leaves (balanoy), Piper nigrum L. seeds (paminta), Vitex negundo L. leaves (lagundi), and Zingiber officinale Roscoe rhizome (luya). This review provides a shortlist that can guide research on possible solutions to COVID-19 using Philippine medicinal plants.
Keywords
Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Non-food/Non-feed Plant Products [SS200]; Pesticides and Drugs; Control [HH405]; Human Immunology and Allergology [VV055]; medicinal plants; plant extracts; coronavirus disease 2019; leaves; plant composition; immunomodulatory properties; antiviral properties; viral diseases; human diseases; reviews; coconuts; seeds; rhizomes; black pepper; ginger; Severe acute respiratory syndrome coronavirus 2; man; Allium; Andrographis paniculata; Cocos nucifera; Euphorbia hirta; Euphorbia neriifolia; Moringa oleifera; Ocimum basilicum; Piper nigrum; Vitex negundo; Zingiber officinale; plants; Philippines; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; APEC countries; ASEAN Countries; high Human Development Index countries; lower-middle income countries; South East Asia; Asia; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Amaryllidaceae; Asparagales; monocotyledons; angiosperms; Spermatophyta; Andrographis; Acanthaceae; Lamiales; eudicots; Cocos; Arecaceae; Arecales; commelinids; Euphorbia; Euphorbiaceae; Malpighiales; Moringa; Moringaceae; Brassicales; Ocimum; Lamiaceae; Piper; Piperaceae; Piperales; magnoliids; Vitex; Verbenaceae; Zingiber; Zingiberaceae; Zingiberales; drug plants; medicinal herbs; officinal plants; SARS-CoV-2; chemical constituents of plants; anti-viral properties; viral infections
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Collection: Databases of international organizations Database: CAB Abstracts Topics: Traditional medicine Language: English Journal: Philippine Journal of Science Year: 2021 Document Type: Article

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Collection: Databases of international organizations Database: CAB Abstracts Topics: Traditional medicine Language: English Journal: Philippine Journal of Science Year: 2021 Document Type: Article