Does Olfactory Dysfunction Correlate with Disease Progression in Parkinson’s Disease? A Systematic Review of the Current Literature
Brain Sciences
; 12(5):513, 2022.
Article
in English
| ProQuest Central | ID: covidwho-1870891
ABSTRACT
Background. Loss of olfaction is a well-established early feature of Parkinson’s disease (PD). Although olfactory dysfunction has been widely described as a prodromal feature of PD in the literature, whether it can be considered a biomarker of PD progression is still a matter of debate. Objective. The aim of this work is to define the possible relationship between the progression of olfactory dysfunction and other putative clinical hallmarks of PD over time, through a systematic review of the current literature. Methods. We conducted a systematic review of the literature on PubMed from inception to March 2022. We included only longitudinal studies conducted on patients with diagnosis of idiopathic PD who underwent olfactory function testing at baseline and repeated it at least once during follow-up. Results. Among 5740 records identified through database searching, nine longitudinal studies met full criteria and underwent data extraction. Conclusions. Olfaction seemed to decrease over time, albeit with a degree of fluctuation. Moreover, smell detection ability seems to deteriorate more rapidly in the early phase of disease, indicating a possible association with disease progression. More studies are needed to better understand the role of olfaction as a biomarker of PD progression over time.
Medical Sciences--Psychiatry And Neurology; Parkinson’s disease; olfactory dysfunction; disease progression; smell; olfaction; Parkinson's disease; Literature reviews; Movement disorders; Severe acute respiratory syndrome coronavirus 2; Parkinsons disease; Biomarkers; Clinical trials; Cognitive ability; Neurodegenerative diseases; Systematic review; Longitudinal studies; COVID-19; Alzheimers disease
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Collection:
Databases of international organizations
Database:
ProQuest Central
Type of study:
Reviews
/
Systematic review/Meta Analysis
Language:
English
Journal:
Brain Sciences
Year:
2022
Document Type:
Article
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