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Adverse events following BNT162b2 mRNA COVID-19 vaccination among healthcare workers: A single-centre experience in Malaysia.
Gan, L L; Zahidah, A R; Hazirah, T; Nabilah, H K; Aisyah, Z; Amin, I N M; Ng, D C E.
  • Gan LL; Hospital Tuanku Ja'afar Seremban, Clinical Research Centre, Negeri Sembilan, Malaysia. lilian.gan@gmail.com.
  • Zahidah AR; Hospital Tuanku Ja'afar Seremban, Occupational Safety and Health Unit, Negeri Sembilan, Malaysia.
  • Hazirah T; Hospital Tuanku Ja'afar Seremban, Occupational Safety and Health Unit, Negeri Sembilan, Malaysia.
  • Nabilah HK; Hospital Tuanku Ja'afar Seremban, Occupational Safety and Health Unit, Negeri Sembilan, Malaysia.
  • Aisyah Z; Hospital Tuanku Ja'afar Seremban, Occupational Safety and Health Unit, Negeri Sembilan, Malaysia.
  • Amin INM; Hospital Tuanku Ja'afar Seremban, Clinical Research Centre, Negeri Sembilan, Malaysia.
  • Ng DCE; Hospital Tuanku Ja'afar Seremban, Department of Paediatrics, Negeri Sembilan, Malaysia.
Med J Malaysia ; 77(3): 300-305, 2022 05.
Article in English | MEDLINE | ID: covidwho-1870942
ABSTRACT

INTRODUCTION:

The COVID-19 pandemic is a global health crisis that has resulted in a massive disease burden worldwide. Mass vaccination plays an important role in controlling the spread and severity of COVID-19 infections worldwide. MATERIALS AND

METHODS:

A cross-sectional study was conducted in Hospital Tuanku Ja'afar Seremban between 1 March 2021 and 4 May 2021 to describe the adverse events (AE) following BNT162b2 (Pfizer-BioNTech) vaccination. Healthcare personnel who received at least one dose of the vaccine were invited to complete an online questionnaire.

RESULTS:

Of 2282 analysed samples, AE were experienced in up to 64.5% (n=1472) of the study participants. Most AE were encountered after the second dose (56.5%, n=832). Pain at the injection site (41.5%, n=944), fever (35.1%, n=798) and lethargy (34.8%, n=792) were the most commonly reported AE. Severe AEFI were reported in a minority (2.9%, n=68). There were no documented anaphylaxis, vaccine-induced thrombosis, or myocarditis. The proportion of female recipients and recipients with a history of allergy were higher in the AE group compared to the non-AE group.

CONCLUSION:

Our study reinforces the safety of the BNT162b2 mRNA vaccine in the local population. The main adverse events were mild, although they occurred in most patients.
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Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Female / Humans Country/Region as subject: Asia Language: English Journal: Med J Malaysia Year: 2022 Document Type: Article Affiliation country: Malaysia

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Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Female / Humans Country/Region as subject: Asia Language: English Journal: Med J Malaysia Year: 2022 Document Type: Article Affiliation country: Malaysia