Prospects in GSK-3 Signaling: From Cellular Regulation to Disease Therapy

ABSTRACT

[...]the incorrect regulation of these pathways as a result of GSK-3 hyperactivity impairs normal cellular homeostasis. [...]disruptions to the normal niche function, reflected by GSK-3 hyperactivity, may be used as a diagnostic tool to detect aberrant activity of stem cells [5]. [...]the absence of GSK-3 improved glucose tolerance (GTT) in insulin-resistant animals fed a high-fat diet (HFD), but did not affect their body weight. [...]maintaining a healthy weight is of prime importance for patients on chronic lithium therapy [10].