Marine Microbial Diversity as Source of Bioactive Compounds
Marine Drugs
; 20(5):304, 2022.
Article
in English
| ProQuest Central | ID: covidwho-1871726
ABSTRACT
Four new cytotoxic indole-diterpenoids (penerpenes K-N), along with twelve other known compounds, have been discovered by Dai et al. from the fermentation broth produced by adding L-tryptophan to the culture medium of Penicillium sp. Three compounds (penerpene N, epipaxilline, emindole SB) were found to be cytotoxic to cancer cell lines, of which the known compound, epipaxilline, was the most active and showed cytotoxic activity against the human liver cancer cell line BeL-7402 with an IC50 value of 5.3 μM. Moreover, six compounds, namely paxilline, 7-hydroxyl-13-dehydroxypaxilline, 7-hydroxypaxilline-13-ene, 4a-demethylpaspaline-4a-carboxylic acid, PC-M6 and emindole SB, showed antibacterial activities against Staphylococcus aureus ATCC 6538 and Bacillus subtilis ATCC 6633 [3]. [...]the authors of this manuscript have also reported, for the first time, a putative lysosomal acid lipase produced by a green microalgae [7]. In this review, the authors have summarized the list of 145 natural products isolated from microorganisms associated with sea cucumbers between 2000 and 2021, which include polyketides, alkaloids and terpenoids as well as their reported biological activities [8].
Pharmacy And Pharmacology; Cytotoxicity; Natural products; Carboxylic acids; Tryptophan; Diterpenes; Polyketides; Liver cancer; Fermentation; Severe acute respiratory syndrome coronavirus 2; Cell culture; Antibacterial activity; Bacteria; L-Tryptophan; Metabolism; Cancer; Biological activity; Bioactive compounds; Terpenes; Marine invertebrates; Microorganisms; Algae; Antibiotics; Phytoplankton; Fungi; Hepatocytes; Culture media; Tumor cell lines; Coronaviruses; Metabolites
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Collection:
Databases of international organizations
Database:
ProQuest Central
Language:
English
Journal:
Marine Drugs
Year:
2022
Document Type:
Article
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