Gender Differences in Takotsubo Syndrome.
J Am Coll Cardiol
; 79(21): 2085-2093, 2022 05 31.
Article
in English
| MEDLINE | ID: covidwho-1872038
ABSTRACT
BACKGROUND:
Male sex in takotsubo syndrome (TTS) has a low incidence and it is still not well characterized.OBJECTIVES:
The aim of the present study is to describe TTS sex differences.METHODS:
TTS patients enrolled in the international multicenter GEIST (GErman Italian Spanish Takotsubo) registry were analyzed. Comparisons between sexes were performed within the overall cohort and using an adjusted analysis with 11 propensity score matching for age, comorbidities, and kind of trigger.RESULTS:
In total, 286 (11%) of 2,492 TTS patients were men. Male patients were younger (age 69 ± 13 years vs 71 ± 11 years; P = 0.005), with higher prevalence of comorbid conditions (diabetes mellitus 25% vs 19%; P = 0.01; pulmonary diseases 21% vs 15%; P = 0.006; malignancies 25% vs 13%; P < 0.001) and physical trigger (55 vs 32% P < 0.01). Propensity-score matching yielded 207 patients from each group. After 11 propensity matching, male patients had higher rates of cardiogenic shock and in-hospital mortality (16% vs 6% and 8% vs 3%, respectively; both P < 0.05). Long-term mortality rate was 4.3% per patient-year (men 10%, women 3.8%). Survival analysis showed higher mortality rate in men during the acute phase in both cohorts (overall P < 0.001; matched P = 0.001); mortality rate after 60 days was higher in men in the overall (P = 0.002) but not in the matched cohort (P = 0.541). Within the overall population, male sex remained independently associated with both in-hospital (OR 2.26; 95% CI 1.16-4.40) and long-term mortality (HR 1.83; 95% CI 1.32-2.52).CONCLUSIONS:
Male TTS is featured by a distinct high-risk phenotype requiring close in-hospital monitoring and long-term follow-up.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Takotsubo Cardiomyopathy
Type of study:
Cohort study
/
Diagnostic study
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
J Am Coll Cardiol
Year:
2022
Document Type:
Article
Affiliation country:
J.jacc.2022.03.366
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