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The outcomes of favipiravir exposure in pregnancy: a case series.
Ertem, Ozge; Guner, Ozge; Incir, Canet; Kalkan, Sule; Gelal, Ayse.
  • Ertem O; Department of Medical Pharmacology, University of Health Sciences Izmir Bozyaka Education and Research Hospital, Izmir, Turkey.
  • Guner O; Department of Medical Pharmacology, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
  • Incir C; Department of Medical Pharmacology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.
  • Kalkan S; Department of Medical Pharmacology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.
  • Gelal A; Department of Medical Pharmacology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey. ayse.gelal@deu.edu.tr.
Arch Gynecol Obstet ; 2022 May 27.
Article in English | MEDLINE | ID: covidwho-2294749
ABSTRACT

PURPOSE:

As in vitro and in vivo studies reported antiviral efficacy against RNA viruses, favipiravir, a pyrazinecarboxamide derivative, has become one of the treatment options for COVID-19 in some countries including Turkey. Preclinical studies demonstrated the risk for teratogenicity and embryotoxicity. Hence, the drug is contraindicated during pregnancy. Although limited in numbers, case-based evaluations indicate that favipiravir might not be a major teratogen in human pregnancies. This study aimed to present and analyze the outcomes of favipiravir exposure during pregnancy.

METHODS:

In this case series, the outcomes of nine pregnancies that were referred to the Teratology Information Service of Dokuz Eylul University Faculty of Medicine, Department of Medical Pharmacology between 01 April 2020 and 30 November 2021 were retrospectively evaluated.

RESULTS:

One spontaneous abortion, two elective terminations, one preterm live delivery and five term live deliveries were detected. The premature newborn was reported dead on the 5th day of neonatal intensive care unit admission. Physiological jaundice and transient respiratory distress were recorded in two term infants. One term infant was antenatally diagnosed with renal pelviectasis, but the findings resolved postnatally without requiring intervention.

CONCLUSION:

The data indicate that favipiravir is not likely to be a major teratogen. Yet, it is not possible to draw a definite conclusion due to methodological limitations. Favipiravir exposures during pregnancy should be followed up closely and the outcomes should be reported consistently.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal subject: Gynecology / Obstetrics Year: 2022 Document Type: Article Affiliation country: S00404-022-06615-z

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal subject: Gynecology / Obstetrics Year: 2022 Document Type: Article Affiliation country: S00404-022-06615-z