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Acute cardiac side effects after COVID-19 mRNA vaccination: a case series.
Freise, Noemi F; Kivel, Milena; Grebe, Olaf; Meyer, Christian; Wafaisade, Bahram; Peiper, Matthias; Zeus, Tobias; Schmidt, Jan; Neuwahl, Judith; Jazmati, Danny; Luedde, Tom; Bölke, Edwin; Feldt, Torsten; Jensen, Björn Erik Ole; Bode, Johannes; Keitel, Verena; Haussmann, Jan; Tamaskovics, Balint; Budach, Wilfried; Fischer, Johannes C; Knoefel, Wolfram Trudo; Schneider, Marion; Gerber, Peter Arne; Pedoto, Alessia; Häussinger, Dieter; van Griensven, Martijn; Rezazadeh, Amir; Flaig, Yechan; Kirchner, Julian; Antoch, Gerald; Schelzig, Hubert; Matuschek, Christiane.
  • Freise NF; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Kivel M; Department of Pediatric, University Hospital Düsseldorf, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
  • Grebe O; Department of Cardiology and Rhythmology, Petrus Hospital, Wuppertal, Germany.
  • Meyer C; Department for Cardiology, Rhythmology, Angiology and Intensive Care Medicine, cNEP Research Consortium, EVK Düsseldorf, Düsseldorf, Germany.
  • Wafaisade B; Department for Cardiology, Rhythmology, Angiology and Intensive Care Medicine, cNEP Research Consortium, EVK Düsseldorf, Düsseldorf, Germany.
  • Peiper M; Department for Cardiology, Rhythmology, Angiology and Intensive Care Medicine, cNEP Research Consortium, EVK Düsseldorf, Düsseldorf, Germany.
  • Zeus T; Medical Faculty, Department of Cardiology, University Hospital of Düsseldorf, Düsseldorf, Germany.
  • Schmidt J; Medical Faculty, Department of Cardiology, University Hospital of Düsseldorf, Düsseldorf, Germany.
  • Neuwahl J; Department of Radiation Oncology, University Hospital, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.
  • Jazmati D; Department of Radiation Oncology, University Hospital, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.
  • Luedde T; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Bölke E; Department of Radiation Oncology, University Hospital, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany. boelke@med.uni-duesseldorf.de.
  • Feldt T; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Jensen BEO; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Bode J; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Keitel V; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Haussmann J; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Magdeburg, Medical Faculty of Otto Von Guericke University Magdeburg, Leipziger Str. 44, 39104, Magdeburg, Germany.
  • Tamaskovics B; Department of Radiation Oncology, University Hospital, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.
  • Budach W; Department of Radiation Oncology, University Hospital, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.
  • Fischer JC; Department of Radiation Oncology, University Hospital, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.
  • Knoefel WT; Institute for Transplant Diagnostics and Cell Therapeutics, Heinrich Heine University, Düsseldorf, Germany.
  • Schneider M; Medical Faculty, Department of Surgery and Interdisciplinary Surgical Intensive Care Unit, Heinrich Heine University, Düsseldorf, Germany.
  • Gerber PA; Division of Experimental Anesthesiology, University Hospital Ulm, Ulm, Germany.
  • Pedoto A; Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
  • Häussinger D; Department of Anesthesiology, Memorial Sloan Kettering Cancer Center, NY, USA.
  • van Griensven M; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Rezazadeh A; Department cBITE, Maastricht University, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht, The Netherlands.
  • Flaig Y; Department of Radiation Oncology, University Hospital, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.
  • Kirchner J; Department of Radiation Oncology, University Hospital, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.
  • Antoch G; Medical Faculty, Department of Diagnostic and Interventional Radiology, University Hospital of Düsseldorf, Dusseldorf, Germany.
  • Schelzig H; Medical Faculty, Department of Diagnostic and Interventional Radiology, University Hospital of Düsseldorf, Dusseldorf, Germany.
  • Matuschek C; Medical Faculty, Department of Vascular Surgery, University Hospital Heinrich Heine University, Düsseldorf, Germany.
Eur J Med Res ; 27(1): 80, 2022 Jun 02.
Article in English | MEDLINE | ID: covidwho-1875029
ABSTRACT

BACKGROUND:

Vaccination against SARS-CoV-2 has been the main tool to contain the pandemic. The rush development of the 3 vaccines and their expedited approval have led to inoculation of millions of patients around the world, leading to a containment of the disease. Despite continuous viral mutations and the identification of weaker variants, the severity of the infections has been mild, with many patients being either asymptomatic or recovering at home. Currently the focus has shifted from the host of organ damage related to the infection to potential side effects of the vaccine. Myocarditis has been reported as one of the potential side effects from the mRNA vaccine, affecting young healthy individuals. Up to September 30, 2021, 1.243 cases of myocarditis after vaccination with BNT162b2 Comirnaty© were registered in young adults by the Paul-Ehrlich-Institute in Germany alone. The exact pathophysiology and the risk factors for myocarditis following vaccination remain unclear. We present a case series of eight patients with cardiac symptom shortly after SARS-CoV-2 mRNA vaccination (BNT162b6, Biontech, Comirnaty© or mRNA-1237 Moderna, Spikevax©). PATIENTS AND

METHODS:

Eight patients between 13 and 56 years of age, vaccinated with either BNT162b2 or mRNA-1273 mRNA vaccine between January and August 2021 developed cardiac side effects shortly after either their first or second dose of the vaccine. Clinical data were retrieved from the clinical information system and analyzed. To support diagnosis of myocarditis or pericarditis, cardiac magnetic resonance imaging (MRI) was performed shortly after the onset of symptoms, with further investigations in severe cases. Symptoms were defined as dyspnea, chest pain and cardiac arrhythmia as determined by electrocardiography.

RESULTS:

Eight patients (5 males and 3 females) developed cardiac symptoms compatible with myocarditis, according to the CDC criteria, shortly after SARS-CoV-2 mRNA vaccination. Three patients (2 males, 1 female) required hospitalization due to severe chest pain and elevated troponin levels. All patients recovered fully within 7 days from the symptom onset.

CONCLUSIONS:

Our data suggest that cardiac adverse events such as myocarditis or pericarditis shortly after SARS-CoV-2 mRNA vaccination are rare but possible and occur particularly in male patients.
Subject(s)
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / COVID-19 / MRNA Vaccines / BNT162 Vaccine / Myocarditis Type of study: Prognostic study / Risk factors Topics: Vaccines / Variants Limits: Adolescent / Adult / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Eur J Med Res Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: S40001-022-00695-y

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / COVID-19 / MRNA Vaccines / BNT162 Vaccine / Myocarditis Type of study: Prognostic study / Risk factors Topics: Vaccines / Variants Limits: Adolescent / Adult / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Eur J Med Res Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: S40001-022-00695-y