Clinical and Imaging Determinants of Neurocognitive Disorders in Post-Acute COVID-19 Patients with Cognitive Complaints.
J Alzheimers Dis
; 87(3): 1239-1250, 2022.
Article
in English
| MEDLINE | ID: covidwho-1875364
ABSTRACT
BACKGROUND:
Neurocognitive disorders (NCDs) are a part of the post-acute coronavirus disease (COVID-19) syndrome. No study has specifically evaluated NCDs in post-acute COVID-19 patients with cognitive complaints or their MRI determinants.OBJECTIVE:
To characterize NCDs in post-acute COVID-19 patients with cognitive complaints. The secondary objectives were to assess their clinical and MRI determinants.METHODS:
We included 46 patients with a post-acute COVID-19 cognitive complaint referred to the Amiens University Hospital Memory Center. They underwent a neuropsychological assessment and 36 had cerebral MRI. The G3 overall summary score was the sum of the mean z scores for the executive function, language, and action speed domains. Neuropsychological profiles were compared in a general linear model. Clinical determinants were analyzed by stepwise linear regression. White matter hyperintensities (WMH) masks were analyzed using parcel-based WMH symptom mapping to identify the locations of WMHs associated with cognitive performance.RESULTS:
Repeated ANOVA showed a group effect (pâ=â0.0001) due to overall lower performance for patients and a domain effect (pâ=â0.0001) due to a lower (pâ=â0.007) action speed score. The G3 overall summary score was significantly associated with solely the requirement for oxygen (R2â=â0.319, pâ=â0.031). WHMs were associated with the G3 overall summary score in the following structures, all right-sided (pâ<â0.01) superior frontal region, postcentral region, cingulum, cortico-spinal tract, inferior longitudinal fasciculus, internal capsule, and posterior segment of the arcuate fasciculus.CONCLUSION:
Post-acute COVID-19 patients with cognitive complaints had NCD, with prominent action slowing, significantly associated with the acute phase oxygen requirement and a right-sided WMH structure pattern.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Leukoaraiosis
/
White Matter
/
COVID-19
Type of study:
Diagnostic study
/
Experimental Studies
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
J Alzheimers Dis
Journal subject:
Geriatrics
/
Neurology
Year:
2022
Document Type:
Article
Affiliation country:
JAD-215506
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