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Epidemiology and Clinical Characteristics of People with Confirmed SARS-CoV-2 Infection during the Early COVID-19 Pandemic in Saudi Arabia.
Alhamlan, Fatimah S; Almaghrabi, Reem S; Devol, Edward B; Alotaibi, Anwar B; Alageel, Saleh M; Obeid, Dalia A; Alraddadi, Basem M; Althawadi, Sahar I; Mutabagani, Maysoon S; Al-Qahtani, Ahmed A.
  • Alhamlan FS; Department of Infection and Immunity, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
  • Almaghrabi RS; College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
  • Devol EB; Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
  • Alotaibi AB; Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
  • Alageel SM; Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
  • Obeid DA; Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
  • Alraddadi BM; Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
  • Althawadi SI; Department of Infection and Immunity, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
  • Mutabagani MS; National Health Laboratory, Saudi Public Health Authority, Riyadh 13351, Saudi Arabia.
  • Al-Qahtani AA; Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah 11564, Saudi Arabia.
Medicines (Basel) ; 9(5)2022 Apr 21.
Article in English | MEDLINE | ID: covidwho-1875703
ABSTRACT
This study provides epidemiologic and clinical characteristics of 492 consecutive patients diagnosed with SARS-CoV-2 infection at King Faisal Specialist Hospital and Research Centre in Saudi Arabia between March and September 2020. Data were collected from electronic case reports. The cohort was 54% male, with 20.4% aged >60 years, 19.9% aged 31-40 years, and 17% aged 41-50 years. The median incubation period was 16 days, with upper and lower 95% quartiles of 27 and 10 days, respectively. Most patients (79.2%) were symptomatic. Variables significantly different between symptomatic and asymptomatic patients were age, blood oxygen saturation percentage, hemoglobin level, lymphocyte count, neutrophil to lymphocyte (NTL) ratio, and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level. Asymptomatic patients were mostly younger, with lower body mass index and ALT and AST levels but higher lymphocyte counts, NTL ratio, and CD4, CD8, natural killer cell, IgG, and IgM levels. Factors associated with increased risk of mortality were age (>42 years) and comorbidities, particularly diabetes mellitus and hypertension. Patients who were not given an antiviral regimen were associated with better prognosis than patients who received an antiviral regimen (HR, 0.07; 95% CI, 0.011-0.25). These findings will help clinicians and policymakers adopt best management and treatment options for SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Screening study Language: English Year: 2022 Document Type: Article Affiliation country: Medicines9050032

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Screening study Language: English Year: 2022 Document Type: Article Affiliation country: Medicines9050032