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Clearance of Persistent SARS-CoV-2 RNA Detection in a NFκB-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report.
Sabino, Janine S; Amorim, Mariene R; de Souza, William M; Marega, Lia F; Mofatto, Luciana S; Toledo-Teixeira, Daniel A; Forato, Julia; Stabeli, Rodrigo G; Costa, Maria Laura; Spilki, Fernando R; Sabino, Ester C; Faria, Nuno R; Benites, Bruno D; Addas-Carvalho, Marcelo; Stucchi, Raquel S B; Vasconcelos, Dewton M; Weaver, Scott C; Granja, Fabiana; Proenca-Modena, José Luiz; Vilela, Maria Marluce Dos S.
  • Sabino JS; Laboratory of Pediatric Immunology, Center for Investigation in Pediatrics, Faculty of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil.
  • Amorim MR; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil.
  • de Souza WM; World Reference Center for Emerging Viruses, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Marega LF; Laboratory of Pediatric Immunology, Center for Investigation in Pediatrics, Faculty of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil.
  • Mofatto LS; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil.
  • Toledo-Teixeira DA; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil.
  • Forato J; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil.
  • Stabeli RG; Oswaldo Cruz Foundation (Fiocruz-SP), Ribeirão Preto 14049-900, Brazil.
  • Costa ML; Department of Public Health Emergency, Preparedness and Disaster, PAHO/WHO, Brasilia 70312-970, Brazil.
  • Spilki FR; Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil.
  • Sabino EC; One Health Laboratory, Feevale University, Novo Hamburgo 93510-235, Brazil.
  • Faria NR; Tropical Medicine Institute, Medical School, University of São Paulo, São Paulo 5403-907, Brazil.
  • Benites BD; Department of Infectious and Parasitic Disease, Medical School, University of São Paulo, São Paulo 05403-000, Brazil.
  • Addas-Carvalho M; Department of Infectious and Parasitic Disease, Medical School, University of São Paulo, São Paulo 05403-000, Brazil.
  • Stucchi RSB; Department of Zoology, University of Oxford, Oxford OX1 2JD, UK.
  • Vasconcelos DM; MRC Centre for Global Infectious Disease Analysis, J-IDEA, Imperial College London, London SW7 2AZ, UK.
  • Weaver SC; Hematology and Transfusion Medicine Center, University of Campinas, Campinas 13083-878, Brazil.
  • Granja F; Hematology and Transfusion Medicine Center, University of Campinas, Campinas 13083-878, Brazil.
  • Proenca-Modena JL; Division of Infectious Diseases, University of Campinas, Campinas 13083-887, Brazil.
  • Vilela MMDS; Laboratory of Investigation in Dermatology and Immunodeficiencies, Department of Dermatology, Medical School, University of São Paulo, São Paulo 05403-000, Brazil.
Viruses ; 14(5)2022 05 13.
Article in English | MEDLINE | ID: covidwho-1903475
ABSTRACT
Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immunosuppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NFκB-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid / Vaccines / Variants Limits: Female / Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14051042

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid / Vaccines / Variants Limits: Female / Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14051042