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Twelve-Month Longitudinal Serology in SARS-CoV-2 Naïve and Experienced Vaccine Recipients and Unvaccinated COVID-19-Infected Individuals.
Congrave-Wilson, Zion; Cheng, Wesley A; Lee, Yesun; Perez, Stephanie; Turner, Lauren; Marentes Ruiz, Carolyn Jennifer; Mendieta, Shirley; Skura, Adam; Jumarang, Jaycee; Del Valle, Jennifer; Kubale, John; Allen, Emma Kaitlynn; Thomas, Paul G; Gordon, Aubree; Pannaraj, Pia S.
  • Congrave-Wilson Z; Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
  • Cheng WA; Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
  • Lee Y; Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
  • Perez S; Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
  • Turner L; Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
  • Marentes Ruiz CJ; Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
  • Mendieta S; Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
  • Skura A; Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
  • Jumarang J; Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
  • Del Valle J; Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
  • Kubale J; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
  • Allen EK; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Thomas PG; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Gordon A; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
  • Pannaraj PS; Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Vaccines (Basel) ; 10(5)2022 May 20.
Article in English | MEDLINE | ID: covidwho-1875823
ABSTRACT
Longitudinal data comparing SARS-CoV-2 serology in individuals following infection and vaccination over 12 months are limited. This study compared the magnitude, decay, and variability in serum IgG, IgA, and neutralizing activity induced by natural infection (n = 218) or mRNA vaccination in SARS-CoV-2 naïve (n = 143) or experienced (n = 122) individuals over time using enzyme-linked immunosorbent assays and an in vitro virus neutralization assay. Serological responses were found to be highly variable after natural infection compared with vaccination but durable through 12 months. Antibody levels in vaccinated, SARS-CoV-2 naïve individuals peaked by 1 month then declined through 9 months, culminating in non-detectable SARS-CoV-2-specific serum IgA. Individuals with both infection and vaccination showed SARS-CoV-2-specific IgG and IgA levels that were more robust and slower to decline than the other groups; neutralizing activity remained highest in this group at 9 months past vaccination. These data reinforce the benefit of vaccination after SARS-CoV-2 recovery.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Vaccines10050813

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Vaccines10050813