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Association of serum ferritin with COVID-19 in a cross-sectional study of 200 intensive care unit patients in a rural hospital: Is ferritin the forgotten biomarker of mortality in severe COVID-19?
Hulkoti, Vidyashree S; Acharya, Sourya; Kumar, Sunil; Talwar, Dhruv; Khanna, Shivam; Annadatha, Akhilesh; Madaan, Sparsh; Verma, Vinay; Sagar, V V S S.
  • Hulkoti VS; Department of Medicine, Jawaharlal Nehru Medical College, DattaMeghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharastra, India.
  • Acharya S; Department of Medicine, Jawaharlal Nehru Medical College, DattaMeghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharastra, India.
  • Kumar S; Department of Medicine, Jawaharlal Nehru Medical College, DattaMeghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharastra, India.
  • Talwar D; Department of Medicine, Jawaharlal Nehru Medical College, DattaMeghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharastra, India.
  • Khanna S; Department of Medicine, Jawaharlal Nehru Medical College, DattaMeghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharastra, India.
  • Annadatha A; Department of Medicine, Jawaharlal Nehru Medical College, DattaMeghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharastra, India.
  • Madaan S; Department of Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, DattaMeghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharastra, India.
  • Verma V; Department of Medicine, Jawaharlal Nehru Medical College, DattaMeghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharastra, India.
  • Sagar VVSS; Department of Medicine, Jawaharlal Nehru Medical College, DattaMeghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharastra, India.
J Family Med Prim Care ; 11(5): 2045-2050, 2022 May.
Article in English | MEDLINE | ID: covidwho-1875941
ABSTRACT

Background:

The COVID-19 disease caused by the SARS-CoV-2 virus, has toppled the world since first case noted in 2019, and the cases have been increasing there after. This grave effect is caused by the cytokine storm induced inflammation produced by the noxious virus. As it is an inflammatory state, various acute phase reactants are expected to raise; thus serum ferritin is contemplated to increase. Here we aim to anchor serum ferritin as a way marker for diagnosis and management of COVID-19 patients and study its role as a prognostic marker. Another aspect is the association of COVID-19 with the N L ratio; observation has stated that higher N L ratio results in more severe outcome. The study aimed to establish a correlation of COVID-19 severity with serum ferritin in the form of HRCT Score, N L Ratio and Clinical Outcome in the patients admitted in Intensive Care Unit.

Result:

Out of 200 patients who were admitted in the intensive care unit with COVID-19, the association of serum ferritin with N L Ratio and HRCT Score was significant, and the association of serum ferritin with clinical outcome in terms of discharged and expired was found to be statistically significant.

Conclusion:

Serum ferritin was found to be a potent marker for clinical outcome in intensive care unit patients in terms of death versus treated. HRCT Score and NL ratio were found to be correlated with serum ferritin. Therefore, we conclude that serum ferritin may determine the severity of COVID-19 infection and it can be used as a marker for Clinical Outcome thereby making it an often neglected biomarker for predicting prognosis in COVID-19 with most of the physicians focusing mostly on interleukin 6, C Reactive protein and d dimer as a marker of severe COVID infection.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Randomized controlled trials Language: English Journal: J Family Med Prim Care Year: 2022 Document Type: Article Affiliation country: Jfmpc.jfmpc_1921_21

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Randomized controlled trials Language: English Journal: J Family Med Prim Care Year: 2022 Document Type: Article Affiliation country: Jfmpc.jfmpc_1921_21