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Genome sequence analysis of nsp15 from SARS-CoV-2.
Yashvardhini, Niti; Jha, Deepak Kumar; Kumar, Amit; Gaurav, Manjush; Sayrav, Kumar.
  • Yashvardhini N; Department of Microbiology, Patna Women's College, Patna, 800 001, Bihar, India.
  • Jha DK; Department of Zoology, S.M.P. Girls Degree College, Ballia, 277401, Uttar Pradesh, India.
  • Kumar A; Department of Botany, Patna University, Patna-800 005, Bihar, India.
  • Gaurav M; Department of Botany, Patna University, Patna-800 005, Bihar, India.
  • Sayrav K; Department of Chemistry, V.K.S. University, Ara-802301, Bihar India.
Bioinformation ; 18(4): 432-437, 2022.
Article in English | MEDLINE | ID: covidwho-1876089
ABSTRACT
SARS-CoV-2 (Severe Acute Respiratory Syndrome), a causative agent of COVID-19 disease created a pandemic situation worldwide. Nsp15 is a uridine specific endoribonuclease encoded by the genome of SARS-CoV-2. It plays important role in processing viral RNA and, thus evades the host immune system. Therefore, it is of interest to identify mutants of nsp15 amongst Asian SARS-CoV-2 isolates, where a total of 1795 mutations, from 7793 sequences of Asia submitted till 31st January 2022, amongst which A231V, H234Y, K109N, K259R and S261A mutations were found frequent. Hence, we report data on the predicted secondary structure of wild type form followed by hydropathy plot, physiochemical properties, Ramachandran plot, B-cell epitopes prediction and protein modeling of wild type and mutant of nsp15 protein. Data shows that nsp15 of SARS-CoV-2 is a pontential candidate for the development of vaccine to control the infections of SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Journal: Bioinformation Year: 2022 Document Type: Article Affiliation country: 97320630018432

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Journal: Bioinformation Year: 2022 Document Type: Article Affiliation country: 97320630018432