Clinical characteristics and laboratory testing of patient with Sar CoV2 infection

ABSTRACT

Background: Sar CoV2, a novel coronavirus was identified as the cause of respiratory abnormality diseases COVID-19. It has no specific symptoms and the transmission occurs via respiratory droplets or contaminated surfaces. Seroprevalence studies of many diseases have been found to be useful to detect people who were exposed to infection and reveal the burden of the disease. Objectives: This study aimed to assess the correlation between Clinical findings and laboratory testing of patients with Sar CoV2 infection as derived by RT PCR detection and to investigate serological antibody of IgM, IgG in serum of Covid19 hospitalized patients. Materials and methods: The study was conducted on 168 patients with positive RT PCR for COVID-19 during June 2021-January 2022 in Khon Kaen Hospital. The nasopharyngeal swabs and blood samples were obtained on the day of admission. Data collection of patient’s clinical symptoms and laboratory testing were recorded for statistical analysis. We performed CBC and anti Sar CoV2 (IgM,IgG) according to standard laboratory methods. Results: The results indicated that seroprevalence of anti Sar CoV2 in COVID-19 patients was approximately 28% (47/168). The laboratory markers of CBC;as WBC, neutrophil, lymphocyte and platelet demonstrated lower significance. No correlation was observed between Ct of RT PCR with clinical signs and symptoms of COVID-19 patients. In case of RBC, Hemoglobin and Hematocrit, there were also no correlation with clinical characteristics of COVID-19 patients. Conclusion: The study observed that WBC count and platelet count was significantly lower for some cases. However, awareness of these parameters is required, because of the large heterogeneity in test performance. From serological tests it was observed that anti Sar CoV2 is not suitable diagnosis of the acute phase of infection. Both tests can be used to help RT PCR for diagnosis of Sar CoV2 infection. © 2022, Faculty of Associated Medical Sciences, Chiang Mai University. All rights reserved.