From the Origins of SARS-CoV-2 to the Correct Application of BLAST
Chinese Journal of Biochemistry and Molecular Biology
; 38(2):221-227, 2022.
Article
in Chinese
| Scopus | ID: covidwho-1876201
ABSTRACT
Basic local alignment search tool (BLAST) is one of the popular sequence similarity analysis tools. However, some students and researchers just blindly use the default parameters. Moreover, some students are confused about how to choose the right program. In a word, it is prone to be misused and researchers often draw conclusions incorrectly. In view of this, we traced back the internet hot topic in early 2020 - "MORDERATELY STRONG CONFIRMATION OF A LABORATORY ORIGIN OF COVID-19", and took it as teaching materials to guide the student to use BLAST currently through reanalyzing and reproducing the source of errors. Then we arranged an interesting experiment about fabricating dinosaur genes through modifying a chicken gene. In the experimental design to make the students grasp the BLAST tools better, one group fabricated the dinosaur gene and the other group decrypted the added bases. This instructional design could be conducive to cultivate students ' ability about distinguishing different viewpoints correctly, and we hope it can be enlightening and helpful to the teaching of BLAST tools. © 2022 by the authors.
Full text:
Available
Collection:
Databases of international organizations
Database:
Scopus
Language:
Chinese
Journal:
Chinese Journal of Biochemistry and Molecular Biology
Year:
2022
Document Type:
Article
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