Estimation and development of some biophysical characteristics of the drug Favipiravir used in the treatment of corona-virus using green chemistry technology

ABSTRACT

This study included the preparation and identification of copper oxide nanoparticles (CuNPs) prepared from eucalyptus leaf extract using modern and advanced detection and analysis devices XRD, AFM, SEM, UV-Vis, and TEM. The results of the tests indicated that the prepared particles are spherical and rod-shaped, with average diameters ranging from 32.55-37.94 nm, and the results showed that the copper oxide nanoparticles were within the nano-scale, and the wavelength of the drug is (322) nanometers. The factors affecting the loading of the drug (Favipiravir) at a concentration of (40 µg/mL) on the surface of activated charcoal prepared from eucalyptus leaves were studied, as well with a weight of 0.1 g and in the presence of copper oxide nanoparticles with different concentrations. It was found that the equilibrium time is 25 minutes, and the thermodynamic functions were calculated at different temperatures. The results illustrated that the loading process by using exothermic adsorption (physical adsorption), is less random process and spontaneously. The possibility of using the loaded substance (FavipiravirCuNPs) to inhibit microorganisms such as viruses, bacteria, and fungi was studied, and by the presence of the surface active substance sodium dodecyl sulphate SDS, it was found that it has the ability to inhibit by 100%, as a result of the merging of the tail of the superficial active substances with the fatty membrane of the virus, the other microorganisms, its dismantling, and encapsulation of its parts. The vaccines and therapeutic drugs developed on the basis of nano-medicine, which are currently undergoing clinical trials, have the potential to become innovative alternatives to defeat COVID-19 in the future. Copyright © 2022 by SPC (Sami Publishing Company).