COVID-19 susceptibility and clinical outcomes in autoimmune inflammatory rheumatic diseases (AIRDs): a systematic review and meta-analysis.
Eur Rev Med Pharmacol Sci
; 26(10): 3760-3770, 2022 05.
Article
in English
| MEDLINE | ID: covidwho-1876425
ABSTRACT
OBJECTIVE:
This meta-analysis aims to assess the susceptibility to and clinical outcomes of COVID-19 in autoimmune inflammatory rheumatic disease (AIRD) and following AIRD drug use. MATERIALS ANDMETHODS:
We included observational and case-controlled studies assessing susceptibility and clinical outcomes of COVID-19 in patients with AIRD as well as the clinical outcomes of COVID-19 with or without use of steroids and conventional synthetic disease-modifying antirheumatic drugs (csDMARDs).RESULTS:
Meta-analysis including three studies showed that patients with AIRD are not more susceptible to COVID-19 compared to patients without AIRD or the general population (OR 1.11, 95% CI 0.58 to 2.14). Incidence of severe outcomes of COVID-19 (OR 1.34, 95% CI 0.76 to 2.35) and COVID-19 related death (OR 1.21, 95% CI 0.68 to 2.16) also did not show significant difference. The clinical outcomes of COVID-19 among AIRD patients with and without csDMARD or steroid showed that both use of steroid (OR 1.69, 95% CI 0.96 to 2.98) or csDMARD (OR 1.35, 95% CI 0.63 to 3.08) had no effect on clinical outcomes of COVID-19.CONCLUSIONS:
AIRD does not increase susceptibility to COVID-19, not affecting the clinical outcome of COVID-19. Similarly, the use of steroids or csDMARDs for AIRD does not worsen the clinical outcome.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Autoimmune Diseases
/
Rheumatic Diseases
/
Antirheumatic Agents
/
COVID-19 Drug Treatment
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Humans
Language:
English
Journal:
Eur Rev Med Pharmacol Sci
Journal subject:
Pharmacology
/
Toxicology
Year:
2022
Document Type:
Article
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