The Problem of the Antibacterial Drugs Using in the COVID-19 Infection’s Era

ABSTRACT

Introduction. The COVID-19 infection has made its own adjustments not only to public life, but also had a significant impact on the healthcare system. The rapid spread of this infection around the globe caused an explosive rise in the incidence with the development of pneumonia. In this connection, one of the first drugs in therapy was antibacterial. The widespread use of antibacterial drugs in the first year of the pandemic led to an increase in the resistance of microorganisms and an increase in the number of cases of C. difficile infection. Purpose. To assess the state of resistance of clinically significant microorganisms in patients with COVID-19. Materials and methods. The study included clinically significant isolates of microorganisms isolated from the biological material of infectious patients. Who were hospitalized at the City Clinical Infectious Diseases Hospital in 2019–2021. We studied 159 isolates of microorganisms isolated from blood samples, CSF, and 198 C. difficile isolates isolated from patients treated at the City Clinical Infectious Diseases Hospital. Results. The ratio of microorganisms from sterile material has changed. In 2019, more than half of all isolated microorganisms were S. aureus, in 2020 A. baumannii became dominant, and in 2021 – S. aureus and K. pneumoniae. An increase in antibiotic resistance of K. pneumoniae, S. aureus, P. aeruginosa was noted. The resistance of A. baumannii has changed. The number of cases of C. difficile infection has increased. Conclusion. The widespread use of antibacterial drugs also affected the sensitivity of microorganisms inoculated from patients of the infectious disease hospital in Minsk. Thus, the antibiotic resistance of both the gram negative flora and the gram positive flora increased;increased number of cases of C. difficile infection. © 2022, Professionalnye Izdaniya. All rights reserved.